1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea hydrochloride

Base Information

Chemical Name:1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea hydrochloride
CAS No.:1269775-42-9
Molecular Formula:C₂₄H₃₃N₇O₃*ClH
Molecular Weight:504.032
Hs Code.:

1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea hydrochloride

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Chemical Property of 1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea hydrochloride

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Technology Process of 1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea hydrochloride

There total 6 articles about 1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3524-32-1
5-Amino-1,3-dimethylpyrazole

: 1269775-42-9
1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: trichlorophosphate / Inert atmosphere

2: 3 h / 185 °C / Inert atmosphere

3: P,P-dichlorophenylphosphine oxide / 17 h / 150 °C / Inert atmosphere

4: tetrahydrofuran / 20 h / Reflux; Inert atmosphere

5: sulfuric acid / 15 h / 60 °C / Inert atmosphere

6: triethylamine / toluene / 16 h / Reflux; Inert atmosphere

With P,P-dichlorophenylphosphine oxide; sulfuric acid; triethylamine; trichlorophosphate; In tetrahydrofuran; toluene; 1: Vilsmeier-Haack reaction / 1: Vilsmeier-Haack reaction;
DOI:10.1021/jm1012903

Reference yield:

: 769971-53-1
6-hydroxy-1,3-dimethylpyrazolo[5,4-b]pyridin-5-carbonitrile

: 1269775-42-9
1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: P,P-dichlorophenylphosphine oxide / 17 h / 150 °C / Inert atmosphere

2: tetrahydrofuran / 20 h / Reflux; Inert atmosphere

3: sulfuric acid / 15 h / 60 °C / Inert atmosphere

4: triethylamine / toluene / 16 h / Reflux; Inert atmosphere

With P,P-dichlorophenylphosphine oxide; sulfuric acid; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1021/jm1012903

Reference yield:

: 769971-54-2
6-Chloro-1,3-dimethylpyrazolo[5,4-b]pyridine-5-carbonitrile

: 1269775-42-9
1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 20 h / Reflux; Inert atmosphere

2: sulfuric acid / 15 h / 60 °C / Inert atmosphere

3: triethylamine / toluene / 16 h / Reflux; Inert atmosphere

With sulfuric acid; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1021/jm1012903