(R)-(-)-2-methoxy-N-n-propylnorapomorphine hydrochloride

Base Information

• Chemical Name: (R)-(-)-2-methoxy-N-n-propylnorapomorphine hydrochloride
• CAS No.: 126874-83-7
• Molecular Formula: C₂₀H₂₃NO₃*ClH
• Molecular Weight: 361.868
• Mol file: 126874-83-7.mol

Synonyms:

Chemical Property of (R)-(-)-2-methoxy-N-n-propylnorapomorphine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(-)-2-methoxy-N-n-propylnorapomorphine hydrochloride

There total 7 articles about (R)-(-)-2-methoxy-N-n-propylnorapomorphine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(5α,17S)-6,7,8,14-tetradehydro-6-methoxy-17-propyl-4,5-epoxymorphinan-3-ol hydrochloride → (R)-(-)-2-methoxy-N-n-propylnorapomorphine hydrochloride (126874-83-7)

Guidance literature:

With methanesulfonic acid;

DOI:10.1002/hlca.200800438

Reference yield:

N-n-propylnorthebaine (88840-30-6) → (R)-(-)-2-methoxy-N-n-propylnorapomorphine hydrochloride (126874-83-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 96 percent / methanesulfonic acid / 1 h / 90 - 95 °C

2: 99 percent / 48percent HBr, glacial acetic acid / 4 h / 130 °C

3: 1.) NaOH / 1.) DMSO, RT, 1 h, 2.) 80 deg C, 4 h

4: 59 percent / methanol; diethyl ether

5: 1.) BCl₃, 2.) methanol / 1.) CH₂Cl₂, hexane, RT, 4 h, 2.) reflux, 30 min

With methanol; sodium hydroxide; methanesulfonic acid; hydrogen bromide; boron trichloride; acetic acid; In methanol; diethyl ether;

DOI:10.1021/jm00168a040

Reference yield:

R(?)-2,10,11-trihydroxy-N-propyl-noraporphine hydrobromide (77761-73-0,79640-85-0) → (R)-(-)-2-methoxy-N-n-propylnorapomorphine hydrochloride (126874-83-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaOH / 1.) DMSO, RT, 1 h, 2.) 80 deg C, 4 h

2: 59 percent / methanol; diethyl ether

3: 1.) BCl₃, 2.) methanol / 1.) CH₂Cl₂, hexane, RT, 4 h, 2.) reflux, 30 min

With methanol; sodium hydroxide; boron trichloride; In methanol; diethyl ether;

DOI:10.1021/jm00168a040

upstream raw materials:

(R)-(-)-2-methoxy-10,11-(methylenedioxy)-N-n-propylnoraporphine hydrochloride

N-n-propylnorthebaine

R(?)-2,10,11-trihydroxy-N-propyl-noraporphine hydrobromide

C₁₈H₁₉NO₃*ClH