Boc-Asp(O-tBu)ψ-D,L-Phe-OBn

Base Information

Chemical Name:Boc-Asp(O-tBu)ψ-D,L-Phe-OBn
CAS No.:114475-39-7
Molecular Formula:C₃₀H₃₉NO₆
Molecular Weight:509.643
Hs Code.:

Synonyms:

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Chemical Property of Boc-Asp(O-tBu)ψ-D,L-Phe-OBn

Chemical Property:

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Technology Process of Boc-Asp(O-tBu)ψ-D,L-Phe-OBn

There total 9 articles about Boc-Asp(O-tBu)ψ-D,L-Phe-OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 114475-37-5,114475-38-6,131897-78-4,131897-79-5
1-Benzyl 7-tert-Butyl (4RS,5S)-4-Bromo-5-<(tert-butoxycarbonyl)amino>-2-phenylheptenedioate

: 114475-39-7,114475-40-0
Boc-Asp(O-tBu)ψ-D,L-Phe-OBn

Guidance literature:: With zinc; In acetic acid; for 1h; Ambient temperature;
DOI:10.1021/jo00006a027

Reference yield:

: 153248-79-4
N-α-(tert-butoxycarbonyl)-β-tert-butyl-L-aspartal

: 114475-39-7,114475-40-0
Boc-Asp(O-tBu)ψ-D,L-Phe-OBn

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 0.67 h / -10 - -5 °C

2: 89 percent / DMAP, Py / Ambient temperature

3: 1) NMO, OsO₄, 2) NaIO₄ / 1) acetone, t-BuOH, r.t., 5 min., 2) H₂O, 2-4 h

4: CH₂Cl₂ / Ambient temperature

5: 64 percent / Na₂CO₃ / methanol / 0.75 h / Ambient temperature

6: 75 percent / dibromotriphenylphosphorane complex / tetrahydrofuran / 1) 0 deg C, 10 min., 2) r.t., 1.5 h

7: 97 percent / Zn / acetic acid / 1 h / Ambient temperature

With pyridine; dmap; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; sodium carbonate; zinc; dibromotriphenylphosphorane; In tetrahydrofuran; methanol; dichloromethane; acetic acid;
DOI:10.1021/jo00006a027

Reference yield:

: 114475-31-9,114475-32-0
tert-Butyl (3S,4RS)-3-<(tert-Butoxycarbonyl)amino>-4-hydroxy-5-hexenoate

: 114475-39-7,114475-40-0
Boc-Asp(O-tBu)ψ-D,L-Phe-OBn

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / DMAP, Py / Ambient temperature

2: 1) NMO, OsO₄, 2) NaIO₄ / 1) acetone, t-BuOH, r.t., 5 min., 2) H₂O, 2-4 h

3: CH₂Cl₂ / Ambient temperature

4: 64 percent / Na₂CO₃ / methanol / 0.75 h / Ambient temperature

5: 75 percent / dibromotriphenylphosphorane complex / tetrahydrofuran / 1) 0 deg C, 10 min., 2) r.t., 1.5 h

6: 97 percent / Zn / acetic acid / 1 h / Ambient temperature

With pyridine; dmap; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; sodium carbonate; zinc; dibromotriphenylphosphorane; In tetrahydrofuran; methanol; dichloromethane; acetic acid;
DOI:10.1021/jo00006a027