febrifugine dihydrochloride

Base Information

Chemical Name:febrifugine dihydrochloride
CAS No.:27257-66-5
Molecular Formula:C₁₆H₁₉N₃O₃*2ClH
Molecular Weight:374.267
Hs Code.:

Synonyms:

Suppliers and Price of febrifugine dihydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of febrifugine dihydrochloride

Chemical Property:

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Technology Process of febrifugine dihydrochloride

There total 7 articles about febrifugine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1185729-94-5
(+)-(2S,3R)-benzyl 3-hydroxy-2-(2-oxo-3-(4-oxoquinazolin-3(4H)-yl)propyl)piperidine-1-carboxylate

: 27257-66-5,32434-42-7
febrifugine dihydrochloride

Guidance literature:: With hydrogenchloride; palladium on carbon; hydrogen; In methanol; water; for 2h; under 760.051 Torr;
DOI:10.1039/b901670h

Reference yield:

: 1203455-37-1
(2S,3R)-3-benzyloxy-2-[2-oxo-3-(4-oxoquinazolin-3(4H)-yl)propyl]piperidine-1-carboxylic acid benzyl ester

: 27257-66-5,32434-42-7
febrifugine dihydrochloride

Guidance literature:: With hydrogenchloride; water;
DOI:10.1016/j.tetlet.2020.152151

Reference yield:

: C₁₆H₂₃N₃O₄S

: 27257-66-5,32434-42-7
febrifugine dihydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine / tetrahydrofuran / 1 h

1.2: 0.25 h

1.3: 10 h / 50 - 55 °C

2.1: triethylamine / dichloromethane / 0 °C

3.1: palladium dichloride; oxygen; copper(l) chloride / N,N-dimethyl-formamide; water

4.1: trimethylsilyl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

4.2: 1.5 h / 0 - 20 °C / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: hydrogenchloride; water

With hydrogenchloride; trimethylsilyl trifluoromethanesulfonate; water; oxygen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; copper(l) chloride; palladium dichloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 1.1: |Staudinger Azide Reduction / 1.2: |Staudinger Azide Reduction / 1.3: |Staudinger Azide Reduction;
DOI:10.1016/j.tetlet.2020.152151