(+/-)-juziphine

Base Information

• Chemical Name: (+/-)-juziphine
• CAS No.: 28090-93-9
• Molecular Formula: C₁₈H₂₁NO₃
• Molecular Weight: 299.37
• Mol file: 28090-93-9.mol

Synonyms:

Chemical Property of (+/-)-juziphine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-juziphine

There total 6 articles about (+/-)-juziphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

8-Hydroxy-1-(4-hydroxy-benzyl)-7-methoxy-2-methyl-isoquinolinium; iodide → (+/-)-juziphine (28090-93-9)

Guidance literature:

With sodium tetrahydroborate;

Reference yield:

2-benzoyl-8-benzyloxy-1,2-dihydro-7-methoxy-isoquinoline-1-carbonitrile (36547-83-8) → (+/-)-juziphine (28090-93-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) NaH / 1.) benzene, reflux, 10 min, 2.) benzene, reflux

2: 70 percent / aq. KOH / ethanol / Heating

3: 1.) HBr, 2.) zinc / 1.) a) acetic acid, 10 deg C, 10 min, b) 10 deg C, 12 h, 2.) acetic acid, 60 deg C, 30 min

4: methanol / 8 h / Heating

5: 60 percent / sodium borohydride

With potassium hydroxide; sodium tetrahydroborate; hydrogen bromide; sodium hydride; zinc; In methanol; ethanol;

Reference yield:

4-(phenoxymethyl)benzaldehyde (2683-70-7) → (+/-)-juziphine (28090-93-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) NaH / 1.) benzene, reflux, 10 min, 2.) benzene, reflux

2: 70 percent / aq. KOH / ethanol / Heating

3: 1.) HBr, 2.) zinc / 1.) a) acetic acid, 10 deg C, 10 min, b) 10 deg C, 12 h, 2.) acetic acid, 60 deg C, 30 min

4: methanol / 8 h / Heating

5: 60 percent / sodium borohydride

With potassium hydroxide; sodium tetrahydroborate; hydrogen bromide; sodium hydride; zinc; In methanol; ethanol;

upstream raw materials:

2-benzoyl-8-benzyloxy-1,2-dihydro-7-methoxy-isoquinoline-1-carbonitrile

4-(phenoxymethyl)benzaldehyde

1-(4-Hydroxy-benzyl)-7-methoxy-isoquinolin-8-ol