(3S)-3-[(2S)-5-benzyloxycarbonyl-2-{(3S)-3-hydroxy-15-methylhexadecanoyl}aminopentanoyl]oxy-15-methylhexadecanamide

Base Information

Chemical Name:(3S)-3-[(2S)-5-benzyloxycarbonyl-2-{(3S)-3-hydroxy-15-methylhexadecanoyl}aminopentanoyl]oxy-15-methylhexadecanamide
CAS No.:213336-71-1
Molecular Formula:C₄₇H₈₂N₂O₇
Molecular Weight:787.177
Hs Code.:

Synonyms:

Suppliers and Price of (3S)-3-[(2S)-5-benzyloxycarbonyl-2-{(3S)-3-hydroxy-15-methylhexadecanoyl}aminopentanoyl]oxy-15-methylhexadecanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S)-3-[(2S)-5-benzyloxycarbonyl-2-{(3S)-3-hydroxy-15-methylhexadecanoyl}aminopentanoyl]oxy-15-methylhexadecanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S)-3-[(2S)-5-benzyloxycarbonyl-2-{(3S)-3-hydroxy-15-methylhexadecanoyl}aminopentanoyl]oxy-15-methylhexadecanamide

There total 9 articles about (3S)-3-[(2S)-5-benzyloxycarbonyl-2-{(3S)-3-hydroxy-15-methylhexadecanoyl}aminopentanoyl]oxy-15-methylhexadecanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83549-87-5
13-methyltetradecanoic acid chloride

: 213336-71-1
(3S)-3-[(2S)-5-benzyloxycarbonyl-2-{(3S)-3-hydroxy-15-methylhexadecanoyl}aminopentanoyl]oxy-15-methylhexadecanamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine; CH₂Cl₂

1.2: 44.5 percent / 5 h / Heating

2.1: 93 percent / H₂; [Ru₂Cl₄{(S)-BINAP}2]*Et₃N / (+)-camphorsulfonic acid / methanol / 6 h / 65 °C / 3800 - 4560 Torr

3.1: 2.25 g / 1N sodium hydroxide / H₂O; methanol / 1 h / Heating

4.1: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide*HCl / dimethylformamide / 0.5 h

5.1: 90 percent / 28 percent ammonium hydroxide / H₂O; dimethylformamide

6.1: 84 percent / benzotriazole-1-yloxytrispyrrolidino-phosphonium hexafluorop; 4-dimethylaminopyridine / CH₂Cl₂

7.1: 4 N hydrogen chloride / dioxane / 1 h

8.1: 638 mg / 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide*HCl; diisopropylethylamine / dimethylformamide

With hydrogenchloride; dmap; ammonium hydroxide; sodium hydroxide; [Ru₂Cl₄{(S)-BINAP}2]*Et₃N; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; (+)-10-camphorsulfonic acid; In 1,4-dioxane; pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Addition / 1.2: methanolysis / 2.1: Reduction / 3.1: Hydrolysis / 4.1: Esterification / 5.1: Substitution / 6.1: Addition / 7.1: Hydrolysis / 8.1: Addition;
DOI:10.7164/antibiotics.51.655

Reference yield:

: 213197-34-3
methyl 15-methyl-3-oxo-hexadecanoate

: 213336-71-1
(3S)-3-[(2S)-5-benzyloxycarbonyl-2-{(3S)-3-hydroxy-15-methylhexadecanoyl}aminopentanoyl]oxy-15-methylhexadecanamide

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / H₂; [Ru₂Cl₄{(S)-BINAP}2]*Et₃N / (+)-camphorsulfonic acid / methanol / 6 h / 65 °C / 3800 - 4560 Torr

2: 2.25 g / 1N sodium hydroxide / H₂O; methanol / 1 h / Heating

3: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide*HCl / dimethylformamide / 0.5 h

4: 90 percent / 28 percent ammonium hydroxide / H₂O; dimethylformamide

5: 84 percent / benzotriazole-1-yloxytrispyrrolidino-phosphonium hexafluorop; 4-dimethylaminopyridine / CH₂Cl₂

6: 4 N hydrogen chloride / dioxane / 1 h

7: 638 mg / 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide*HCl; diisopropylethylamine / dimethylformamide

With hydrogenchloride; dmap; ammonium hydroxide; sodium hydroxide; [Ru₂Cl₄{(S)-BINAP}2]*Et₃N; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; (+)-10-camphorsulfonic acid; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Reduction / 2: Hydrolysis / 3: Esterification / 4: Substitution / 5: Addition / 6: Hydrolysis / 7: Addition;
DOI:10.7164/antibiotics.51.655

Reference yield:

: 213197-32-1
methyl (S)-3-hydroxy-15-methylhexadecanoate

: 213336-71-1
(3S)-3-[(2S)-5-benzyloxycarbonyl-2-{(3S)-3-hydroxy-15-methylhexadecanoyl}aminopentanoyl]oxy-15-methylhexadecanamide

Guidance literature:: Multi-step reaction with 6 steps

1: 2.25 g / 1N sodium hydroxide / H₂O; methanol / 1 h / Heating

2: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide*HCl / dimethylformamide / 0.5 h

3: 90 percent / 28 percent ammonium hydroxide / H₂O; dimethylformamide

4: 84 percent / benzotriazole-1-yloxytrispyrrolidino-phosphonium hexafluorop; 4-dimethylaminopyridine / CH₂Cl₂

5: 4 N hydrogen chloride / dioxane / 1 h

6: 638 mg / 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide*HCl; diisopropylethylamine / dimethylformamide

With hydrogenchloride; dmap; ammonium hydroxide; sodium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Hydrolysis / 2: Esterification / 3: Substitution / 4: Addition / 5: Hydrolysis / 6: Addition;
DOI:10.7164/antibiotics.51.655