1-methyl N-acetyl-L-glutamic acid

Base Information

Chemical Name:1-methyl N-acetyl-L-glutamic acid
CAS No.:150857-81-1
Molecular Formula:C₈H₁₃NO₅
Molecular Weight:203.195
Hs Code.:

Synonyms:

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Chemical Property of 1-methyl N-acetyl-L-glutamic acid

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Technology Process of 1-methyl N-acetyl-L-glutamic acid

There total 1 articles about 1-methyl N-acetyl-L-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 6234-01-1,16948-36-0
L-glutamic acid 5-tert-butyl 1-methyl ester hydrochloride

: 108-24-7
acetic anhydride

: 150857-81-1,17015-15-5
1-methyl N-acetyl-L-glutamic acid

Guidance literature:: L-glutamic acid 5-tert-butyl 1-methyl ester hydrochloride; With triethylamine; In dichloromethane; at 0 ℃; for 0.0833333h; Inert atmosphere;

acetic anhydride; In dichloromethane; at 20 ℃; for 17h; Inert atmosphere;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.orglett.1c03344

Reference yield:

: C₁₁H₁₀F₃N₃O₂

: 150857-81-1,17015-15-5
1-methyl N-acetyl-L-glutamic acid

: C₁₉H₂₃F₃N₂O₇

Guidance literature:: In neat (no solvent); at 4 ℃; for 0.1h; Photolysis; Inert atmosphere; Sealed tube;
DOI:10.1021/jacs.1c02509

Reference yield:

: 150857-81-1,17015-15-5
1-methyl N-acetyl-L-glutamic acid

: 936952-13-5
C₃₁H₄₄N₄O₁₂S₂

Guidance literature:: Multi-step reaction with 3 steps

1.1: 92 percent / DCC / tetrahydrofuran / 19 h / 0 - 5 °C

2.1: TFA / 2 h / 20 °C

3.1: TEA; isobutyl chloroformate / dimethylformamide / 0.25 h / -15 °C

3.2: dimethylformamide / 19 h / 0 - 5 °C

With TEA; dicyclohexyl-carbodiimide; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm070037v