(S)-benzyl 4-acetamido-5-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-5-oxopentanoate

Base Information

Chemical Name:(S)-benzyl 4-acetamido-5-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-5-oxopentanoate
CAS No.:1564251-62-2
Molecular Formula:C₂₉H₄₃BN₂O₆
Molecular Weight:526.481
Hs Code.:

(S)-benzyl 4-acetamido-5-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-5-oxopentanoate

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Chemical Property of (S)-benzyl 4-acetamido-5-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-5-oxopentanoate

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Technology Process of (S)-benzyl 4-acetamido-5-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-5-oxopentanoate

There total 3 articles about (S)-benzyl 4-acetamido-5-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-5-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₄₁BN₂O₅

: 108-24-7
acetic anhydride

: 1564251-62-2
(S)-benzyl 4-acetamido-5-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-5-oxopentanoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.416667h;
DOI:10.1021/jm500045x

Reference yield:

: 13574-13-5
Boc-Glu(OBzl)-OH

: 1564251-62-2
(S)-benzyl 4-acetamido-5-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-5-oxopentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2: triethylamine / dichloromethane / 14 h / 0 - 20 °C

3: trifluoroacetic acid / dichloromethane / 15 h / 0 - 20 °C

4: triethylamine / dichloromethane / 0.42 h / 0 - 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm500045x

Reference yield:

: (S)-4-tert-Butoxycarbonylamino-5-(2,2-dimethyl-propionyloxy)-5-oxo-pentanoic acid benzyl ester

: 1564251-62-2
(S)-benzyl 4-acetamido-5-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-5-oxopentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 14 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 15 h / 0 - 20 °C

3: triethylamine / dichloromethane / 0.42 h / 0 - 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm500045x