Technology Process of Benzo[b]thiophen-5-ylmethanesulfonyl chloride
There total 1 articles about Benzo[b]thiophen-5-ylmethanesulfonyl chloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-bromobenzo[b]thiophene;
With
tert.-butyl lithium;
In
diethyl ether; pentane;
at -78 - 0 ℃;
With
sulfur dioxide;
In
diethyl ether; pentane;
at -78 - 20 ℃;
With
N-chloro-succinimide;
In
diethyl ether; pentane;
DOI:10.1016/j.bmcl.2004.11.041
- Guidance literature:
-
Multi-step reaction with 2 steps
1: aq. NH3 / acetone / 0 °C
2: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide*HCl; N,N-dimethylaminopyridine / CH2Cl2 / 20 °C
With
dmap; ammonium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane; acetone;
DOI:10.1016/j.bmcl.2004.11.041
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane
2: potassium carbonate / N,N-dimethyl-formamide
3: hydrogenchloride; water / ethyl acetate
4: 4-methyl-morpholine; 2-chloro-1,3-dimethyl-2-imidazolinium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane
With
4-methyl-morpholine; hydrogenchloride; water; potassium carbonate; 2-chloro-1,3-dimethyl-2-imidazolinium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.08.087
