(5S)-Dihydro-5-(4-methylphenyl)-2(3H)-furanone

Base Information

Chemical Name:(5S)-Dihydro-5-(4-methylphenyl)-2(3H)-furanone
CAS No.:128994-27-4
Molecular Formula:C11H12O2
Molecular Weight:176.215
Hs Code.:
DSSTox Substance ID:DTXSID601247108
Nikkaji Number:J2.421.347A

Synonyms:DTXSID601247108;128994-27-4;(5S)-Dihydro-5-(4-methylphenyl)-2(3H)-furanone

Suppliers and Price of (5S)-Dihydro-5-(4-methylphenyl)-2(3H)-furanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5S)-Dihydro-5-(4-methylphenyl)-2(3H)-furanone

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:176.083729621
Heavy Atom Count:13
Complexity:192

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2CCC(=O)O2
Isomeric SMILES:CC1=CC=C(C=C1)[C@@H]2CCC(=O)O2

Technology Process of (5S)-Dihydro-5-(4-methylphenyl)-2(3H)-furanone

There total 18 articles about (5S)-Dihydro-5-(4-methylphenyl)-2(3H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: (S)-N-methyl-4-hydroxy-4-(p-tolyl)butanamide

: 128994-27-4
(S)-γ-(4-methylphenyl)-γ-butyrolactone

Guidance literature:: With sodium hydroxide; In methanol; for 3h; Reflux;
DOI:10.1515/hc-2015-0027

Reference yield: 51.0%

: 36440-63-8
ethyl 4-(4-methylphenyl)butanoate

: 128994-27-4
(S)-γ-(4-methylphenyl)-γ-butyrolactone

Guidance literature:: ethyl 4-(4-methylphenyl)butanoate; With ketoreductase-P₂-C₀₂; oxygen; NADPH; 9-(2-mesityl)-10-methylacridinium perchlorate; In water; acetonitrile; at 23 ℃; for 24h; Irradiation; Enzymatic reaction;

With isopropyl alcohol; In water; acetonitrile; enantioselective reaction; Enzymatic reaction;
DOI:10.1002/anie.201909426

Reference yield: 46.0%

: C₁₃H₁₅N₃O₂

: 128994-27-4
(S)-γ-(4-methylphenyl)-γ-butyrolactone

Guidance literature:: C₁₃H₁₅N₃O₂; With formic acid; N-[(1S,2S)-1,2-diphenyl-2-(3-phenylpropylamino)ethyl]-4-methylbenzene sulfonamide ammonium chloride ruthenium; triethylamine; In water; at 60 ℃; for 24h; Inert atmosphere;

With trifluoroacetic acid; In dichloromethane; water; for 4h; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol501895k