Technology Process of 14β-3-methoxy-5,7-dihydroxy-5,6-seco-6-oxaestra-1,3,5(10)-trien-17-one
There total 12 articles about 14β-3-methoxy-5,7-dihydroxy-5,6-seco-6-oxaestra-1,3,5(10)-trien-17-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 68 percent / 18-crown-6, KF / acetonitrile / Heating
2: 80 percent / p-toluenesulfonic acid monohydrate / benzene / 15 h / Heating
3: sodium borohydride / benzene; methanol / 1.) 5 min, 2.) room temp., 2 h
4: 82 percent / CrO3/H2SO4 / acetone; H2O / 0.5 h / 20 - 35 °C
5: 95 percent / p-toluenesulfonic acid monohydrate / benzene / 2.5 h / Heating
6: 79 percent / Li, liq. NH3 / 0.5 h
With
chromium(VI) oxide; potassium fluoride; sodium tetrahydroborate; 18-crown-6 ether; sulfuric acid; ammonia; lithium; toluene-4-sulfonic acid;
In
methanol; water; acetone; acetonitrile; benzene;
DOI:10.1139/v80-224
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 94 percent / cc.H2SO4 / 15 h / Ambient temperature
2: 82 percent / acetonitrile / 18 h / Heating
3: 91 percent / 15percent Na2CO3 / 2 h / Ambient temperature
4: 68 percent / 18-crown-6, KF / acetonitrile / Heating
5: 80 percent / p-toluenesulfonic acid monohydrate / benzene / 15 h / Heating
6: sodium borohydride / benzene; methanol / 1.) 5 min, 2.) room temp., 2 h
7: 82 percent / CrO3/H2SO4 / acetone; H2O / 0.5 h / 20 - 35 °C
8: 95 percent / p-toluenesulfonic acid monohydrate / benzene / 2.5 h / Heating
9: 79 percent / Li, liq. NH3 / 0.5 h
With
chromium(VI) oxide; potassium fluoride; sodium tetrahydroborate; 18-crown-6 ether; sulfuric acid; ammonia; lithium; sodium carbonate; toluene-4-sulfonic acid;
In
methanol; water; acetone; acetonitrile; benzene;
DOI:10.1139/v80-224
