Technology Process of (4aS,5aR,12aS)-9-Benzoyl-7-dimethylamino-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide
There total 6 articles about (4aS,5aR,12aS)-9-Benzoyl-7-dimethylamino-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide which
guide to synthetic route it.
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synthetic route:
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1035978-20-1
(4aS,5aR,12aS)-9-Benzoyl-7-dimethylamino-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide
- Guidance literature:
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Multi-step reaction with 2 steps
1.1: 1-methyl-pyrrolidin-2-one / 3.5 h / 20 - 80 °C
1.2: pH 1
2.1: trifuran-2-yl-phosphane / tris-(dibenzylideneacetone)dipalladium(0) / tetrahydrofuran / 90 °C / Inert atmosphere
With
trifuran-2-yl-phosphane;
tris-(dibenzylideneacetone)dipalladium(0);
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one;
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1035978-20-1
(4aS,5aR,12aS)-9-Benzoyl-7-dimethylamino-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide
- Guidance literature:
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Multi-step reaction with 7 steps
1.1: sodium hydrogencarbonate / water / pH 6.5 - 7
2.1: methyl iodide / tetrahydrofuran / 16 h / 40 - 45 °C / Inert atmosphere
3.1: trifluoroacetic acid; zinc / water; N,N-dimethyl-formamide / 3 h / 5 °C
3.2: pH 3.5
4.1: methanesulfonic acid; iodine; silver sulfate / 3 h / Inert atmosphere
4.2: pH 7
5.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium(0) / 1-methyl-pyrrolidin-2-one / 60 °C / 20 - 760.05 Torr / Inert atmosphere
6.1: 1-methyl-pyrrolidin-2-one / 3.5 h / 20 - 80 °C
6.2: pH 1
7.1: trifuran-2-yl-phosphane / tris-(dibenzylideneacetone)dipalladium(0) / tetrahydrofuran / 90 °C / Inert atmosphere
With
methanesulfonic acid; trifuran-2-yl-phosphane; iodine; sodium hydrogencarbonate; silver sulfate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; zinc; methyl iodide;
tris-(dibenzylideneacetone)dipalladium(0); tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide;
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1035978-20-1
(4aS,5aR,12aS)-9-Benzoyl-7-dimethylamino-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: methanesulfonic acid; iodine; silver sulfate / 3 h / Inert atmosphere
1.2: pH 7
2.1: N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium(0) / 1-methyl-pyrrolidin-2-one / 60 °C / 20 - 760.05 Torr / Inert atmosphere
3.1: 1-methyl-pyrrolidin-2-one / 3.5 h / 20 - 80 °C
3.2: pH 1
4.1: trifuran-2-yl-phosphane / tris-(dibenzylideneacetone)dipalladium(0) / tetrahydrofuran / 90 °C / Inert atmosphere
With
methanesulfonic acid; trifuran-2-yl-phosphane; iodine; silver sulfate; N-ethyl-N,N-diisopropylamine;
tris-(dibenzylideneacetone)dipalladium(0); tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one;