4-{4-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-4-((S)-2-tert-butylcarbamoyl-piperidin-1-yl)-3-hydroxy-butyl]-phenoxy}-butyric acid

Base Information

• Chemical Name: 4-{4-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-4-((S)-2-tert-butylcarbamoyl-piperidin-1-yl)-3-hydroxy-butyl]-phenoxy}-butyric acid
• CAS No.: 185303-94-0
• Molecular Formula: C₂₈H₄₅N₅O₇
• Molecular Weight: 563.695
• Mol file: 185303-94-0.mol

Synonyms:

Chemical Property of 4-{4-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-4-((S)-2-tert-butylcarbamoyl-piperidin-1-yl)-3-hydroxy-butyl]-phenoxy}-butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{4-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-4-((S)-2-tert-butylcarbamoyl-piperidin-1-yl)-3-hydroxy-butyl]-phenoxy}-butyric acid

There total 1 articles about 4-{4-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-4-((S)-2-tert-butylcarbamoyl-piperidin-1-yl)-3-hydroxy-butyl]-phenoxy}-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butyloxycarbonylasparagine (7536-55-2) + (S)-Piperidine-2-carboxylic acid tert-butylamide; hydrochloride + 1-bromo-(S)-3-<(tert-butoxycarbonyl)amino>-4-<4'-<(3'-carbethoxypropyl)oxy>phenyl>-2-butanone (171858-34-7) → 4-{4-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-4-((S)-2-tert-butylcarbamoyl-piperidin-1-yl)-3-hydroxy-butyl]-phenoxy}-butyric acid (185303-94-0)

Guidance literature:

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;

DOI:10.1016/0960-894X(96)00468-4

Reference yield:

4-{4-[(S)-2-((S)-2-Amino-3-carbamoyl-propionylamino)-4-((S)-2-tert-butylcarbamoyl-piperidin-1-yl)-3-hydroxy-butyl]-phenoxy}-butyric acid (185303-94-0) → (S)-1-[(S)-2-((8S,11S)-8-Carbamoylmethyl-6,9-dioxo-2-oxa-7,10-diaza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-trien-11-yl)-2-hydroxy-ethyl]-piperidine-2-carboxylic acid tert-butylamide + (S)-1-[(R)-2-((8S,11S)-8-Carbamoylmethyl-6,9-dioxo-2-oxa-7,10-diaza-bicyclo[11.2.2]heptadeca-1(16),13(17),14-trien-11-yl)-2-hydroxy-ethyl]-piperidine-2-carboxylic acid tert-butylamide

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;

DOI:10.1016/0960-894X(96)00468-4

upstream raw materials:

N-tert-butyloxycarbonylasparagine

1-bromo-(S)-3-<(tert-butoxycarbonyl)amino>-4-<4'-<(3'-carbethoxypropyl)oxy>phenyl>-2-butanone