Technology Process of Glycine,
N-[N-[N-[N-[5-nitro-2-(phenoxymethyl)benzoyl]glycyl]glycyl]glycyl]-, ethyl
ester
There total 6 articles about Glycine,
N-[N-[N-[N-[5-nitro-2-(phenoxymethyl)benzoyl]glycyl]glycyl]glycyl]-, ethyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: AcCl / Heating
2: N-bromosuccinimide (NBS), benzoyl peroxide / CCl4 / 20 h / Heating
3: NaOH, tricaprylmethylammonium chloride / CH2Cl2; H2O / 5 h / Ambient temperature
4: 82 percent / aq. 4 N KOH / methanol / 4 h / Ambient temperature
5: SOCl2, DMF / 3 h / Ambient temperature
6: Et3N / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 2 h
With
potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; thionyl chloride; Perbenzoic acid; Aliquat 336; triethylamine; acetyl chloride; N,N-dimethyl-formamide;
In
methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(91)90119-8
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-bromosuccinimide (NBS), benzoyl peroxide / CCl4 / 20 h / Heating
2: NaOH, tricaprylmethylammonium chloride / CH2Cl2; H2O / 5 h / Ambient temperature
3: 82 percent / aq. 4 N KOH / methanol / 4 h / Ambient temperature
4: SOCl2, DMF / 3 h / Ambient temperature
5: Et3N / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 2 h
With
potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; thionyl chloride; Perbenzoic acid; Aliquat 336; triethylamine; N,N-dimethyl-formamide;
In
methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(91)90119-8
- Guidance literature:
-
Multi-step reaction with 4 steps
1: NaOH, tricaprylmethylammonium chloride / CH2Cl2; H2O / 5 h / Ambient temperature
2: 82 percent / aq. 4 N KOH / methanol / 4 h / Ambient temperature
3: SOCl2, DMF / 3 h / Ambient temperature
4: Et3N / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 2 h
With
potassium hydroxide; sodium hydroxide; thionyl chloride; Aliquat 336; triethylamine; N,N-dimethyl-formamide;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(91)90119-8
