1-[3-(2-deoxy-5-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl)-3H-imidazo[2,1-i]purin-7-yl]-1-hexyl-2-methylpropanoate

Base Information

• Chemical Name: 1-[3-(2-deoxy-5-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl)-3H-imidazo[2,1-i]purin-7-yl]-1-hexyl-2-methylpropanoate
• CAS No.: 586963-15-7
• Molecular Formula: C₄₃H₄₉N₅O₇
• Molecular Weight: 747.891
• Mol file: 586963-15-7.mol

Synonyms:

Chemical Property of 1-[3-(2-deoxy-5-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl)-3H-imidazo[2,1-i]purin-7-yl]-1-hexyl-2-methylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[3-(2-deoxy-5-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl)-3H-imidazo[2,1-i]purin-7-yl]-1-hexyl-2-methylpropanoate

There total 6 articles about 1-[3-(2-deoxy-5-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl)-3H-imidazo[2,1-i]purin-7-yl]-1-hexyl-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 1-[3-(2-deoxy-β-D-erythro-pentofuranosyl)-3H-imidazo[2,1-i]-purin-7-yl]-1-hexyl-2-methylpropanoate (586963-14-6) → 1-[3-(2-deoxy-5-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl)-3H-imidazo[2,1-i]purin-7-yl]-1-hexyl-2-methylpropanoate (586963-15-7)

Guidance literature:

With pyridine; for 1h; cooling;

DOI:10.1016/S0968-0896(03)00125-1

Reference yield:

(E)-2-Octenal (2548-87-0) → 1-[3-(2-deoxy-5-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl)-3H-imidazo[2,1-i]purin-7-yl]-1-hexyl-2-methylpropanoate (586963-15-7)

Guidance literature:

Multi-step reaction with 6 steps

1: Na₂EDTA; trifluoroacetone; Oxone(R) / sodium bicarbonate / acetonitrile; H₂O / 3 h

2: 2.6 g / sodium phosphate buffer / acetonitrile; H₂O / 120 h / 50 °C / pH 7.4

3: 70 percent / triethylamine / dimethylformamide / 2 h

4: 83 percent / pyridine; 4-(dimethylamino)pyridine / 0.5 h

5: 85 percent / cesium fluoride; pyridine / dimethylformamide / 24 h

6: 85 percent / pyridine / 1 h / cooling

With pyridine; dmap; oxone; 1,1,1-trifluoro-2-propanone; sodium phosphate buffer; edetate disodium; triethylamine; cesium fluoride; sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0968-0896(03)00125-1

Reference yield:

2,3-epoxyoctanal (42134-50-9,113973-12-9) → 1-[3-(2-deoxy-5-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl)-3H-imidazo[2,1-i]purin-7-yl]-1-hexyl-2-methylpropanoate (586963-15-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 2.6 g / sodium phosphate buffer / acetonitrile; H₂O / 120 h / 50 °C / pH 7.4

2: 70 percent / triethylamine / dimethylformamide / 2 h

3: 83 percent / pyridine; 4-(dimethylamino)pyridine / 0.5 h

4: 85 percent / cesium fluoride; pyridine / dimethylformamide / 24 h

5: 85 percent / pyridine / 1 h / cooling

With pyridine; dmap; sodium phosphate buffer; triethylamine; cesium fluoride; In water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0968-0896(03)00125-1

upstream raw materials:

4,4'-dimethoxytrityl chloride

1-[3-(2-deoxy-β-D-erythro-pentofuranosyl)-3H-imidazo[2,1-i]-purin-7-yl]-1-hexyl-2-methylpropanoate

(E)-2-Octenal

2,3-epoxyoctanal