(5S,6S)-2-Benzyloxy-1-hydroxymethyl-6-isopropylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol

Base Information

Chemical Name:(5S,6S)-2-Benzyloxy-1-hydroxymethyl-6-isopropylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol
CAS No.:60056-44-2
Molecular Formula:C₂₂H₂₉NO₃
Molecular Weight:355.477
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5S,6S)-2-Benzyloxy-1-hydroxymethyl-6-isopropylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol

Chemical Property:

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Technology Process of (5S,6S)-2-Benzyloxy-1-hydroxymethyl-6-isopropylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol

There total 13 articles about (5S,6S)-2-Benzyloxy-1-hydroxymethyl-6-isopropylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60055-14-3
2-Hydroxy-1-methoxymethyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-on

: 60056-44-2,60056-45-3
(5S,6S)-2-Benzyloxy-1-hydroxymethyl-6-isopropylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol

Guidance literature:: Multi-step reaction with 10 steps

1: potassium carbonate; potassium iodide / methanol / 3 h / Heating

2: hydrogen bromide / acetic acid / 0.83 h / 50 °C

3: sodium hydrogencarbonate; dimethyl sulfoxide / 0.33 h / 100 °C

4: chromium(VI) oxide / acetone

5: potassium carbonate / acetone / 1 h / Heating

6: hydrogenchloride; ethanol; isopentyl nitrite / tetrahydrofuran; diethyl ether / 0 °C

7: hydrogen / nickel / acetic acid / 760 Torr / Ambient temperature

8: sodium tetrahydroborate / ethanol

9: sodium hydroxide / ethanol / 5 h / Heating

10: (i) LiBH₃CN, dioxane, MeOH, (ii) LiAlH₄, THF

With chromium(VI) oxide; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; ethanol; hydrogen bromide; hydrogen; sodium hydrogencarbonate; potassium carbonate; dimethyl sulfoxide; potassium iodide; isopentyl nitrite; nickel; In tetrahydrofuran; methanol; diethyl ether; ethanol; acetic acid; acetone;

Reference yield:

: 60055-13-2
1-Chlormethyl-2-hydroxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-on

: 60056-44-2,60056-45-3
(5S,6S)-2-Benzyloxy-1-hydroxymethyl-6-isopropylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol

Guidance literature:: Multi-step reaction with 11 steps

1: triethylamine / 3 h / Heating

2: potassium carbonate; potassium iodide / methanol / 3 h / Heating

3: hydrogen bromide / acetic acid / 0.83 h / 50 °C

4: sodium hydrogencarbonate; dimethyl sulfoxide / 0.33 h / 100 °C

5: chromium(VI) oxide / acetone

6: potassium carbonate / acetone / 1 h / Heating

7: hydrogenchloride; ethanol; isopentyl nitrite / tetrahydrofuran; diethyl ether / 0 °C

8: hydrogen / nickel / acetic acid / 760 Torr / Ambient temperature

9: sodium tetrahydroborate / ethanol

10: sodium hydroxide / ethanol / 5 h / Heating

11: (i) LiBH₃CN, dioxane, MeOH, (ii) LiAlH₄, THF

With chromium(VI) oxide; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; ethanol; hydrogen bromide; hydrogen; sodium hydrogencarbonate; potassium carbonate; dimethyl sulfoxide; triethylamine; potassium iodide; isopentyl nitrite; nickel; In tetrahydrofuran; methanol; diethyl ether; ethanol; acetic acid; acetone;

Reference yield:

: 60055-16-5
2-Benzyloxy-1-brommethyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-on

: 60056-44-2,60056-45-3
(5S,6S)-2-Benzyloxy-1-hydroxymethyl-6-isopropylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydrogencarbonate; dimethyl sulfoxide / 0.33 h / 100 °C

2: chromium(VI) oxide / acetone

3: potassium carbonate / acetone / 1 h / Heating

4: hydrogenchloride; ethanol; isopentyl nitrite / tetrahydrofuran; diethyl ether / 0 °C

5: hydrogen / nickel / acetic acid / 760 Torr / Ambient temperature

6: sodium tetrahydroborate / ethanol

7: sodium hydroxide / ethanol / 5 h / Heating

8: (i) LiBH₃CN, dioxane, MeOH, (ii) LiAlH₄, THF

With chromium(VI) oxide; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; ethanol; hydrogen; sodium hydrogencarbonate; potassium carbonate; dimethyl sulfoxide; isopentyl nitrite; nickel; In tetrahydrofuran; diethyl ether; ethanol; acetic acid; acetone;