3-oxo-1-demethyl-18-phenylsulphinylvincatine

Base Information

Chemical Name:3-oxo-1-demethyl-18-phenylsulphinylvincatine
CAS No.:113541-92-7
Molecular Formula:C₂₇H₃₀N₂O₅S
Molecular Weight:494.612
Hs Code.:

Synonyms:

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Chemical Property of 3-oxo-1-demethyl-18-phenylsulphinylvincatine

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Technology Process of 3-oxo-1-demethyl-18-phenylsulphinylvincatine

There total 7 articles about 3-oxo-1-demethyl-18-phenylsulphinylvincatine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5851-37-6
4-(phenylthio)butan-1-ol

: 113541-92-7
3-oxo-1-demethyl-18-phenylsulphinylvincatine

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / dimethyl sulphide, N-chlorosuccinimide / toluene / 2 h / -25 °C

2: 97 percent / K₂CO₃ / toluene; diethyl ether / 0 deg C, 1 h and then RT, 3 h

3: 1) 0 deg C, 4 h, and RT, 15 h, then reflux, 48h, methanol, 2) acetic acid, water, reflux, 8 h

4: 15 percent / sodium acetate / ethanol; H₂O / 18 h / Heating

5: 1) m-chloroperbenzoic acid, 2) 10percent sodium sulphite / 1) dichloromethane, -78 deg C, 4 h, 2) ether, water, RT

With N-chloro-succinimide; dimethylsulfide; sodium acetate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium sulfite; In diethyl ether; ethanol; water; toluene;
DOI:10.1016/S0040-4020(01)96092-2

Reference yield:

: 1-((E)-5-Phenylsulfanyl-pent-1-enyl)-pyrrolidine

: 113541-92-7
3-oxo-1-demethyl-18-phenylsulphinylvincatine

Guidance literature:: Multi-step reaction with 3 steps

1: 1) 0 deg C, 4 h, and RT, 15 h, then reflux, 48h, methanol, 2) acetic acid, water, reflux, 8 h

2: 15 percent / sodium acetate / ethanol; H₂O / 18 h / Heating

3: 1) m-chloroperbenzoic acid, 2) 10percent sodium sulphite / 1) dichloromethane, -78 deg C, 4 h, 2) ether, water, RT

With sodium acetate; 3-chloro-benzenecarboperoxoic acid; sodium sulfite; In ethanol; water;
DOI:10.1016/S0040-4020(01)96092-2

Reference yield:

: 108-98-5
thiophenol

: 113541-92-7
3-oxo-1-demethyl-18-phenylsulphinylvincatine

Guidance literature:: Multi-step reaction with 6 steps

2: 77 percent / dimethyl sulphide, N-chlorosuccinimide / toluene / 2 h / -25 °C

3: 97 percent / K₂CO₃ / toluene; diethyl ether / 0 deg C, 1 h and then RT, 3 h

4: 1) 0 deg C, 4 h, and RT, 15 h, then reflux, 48h, methanol, 2) acetic acid, water, reflux, 8 h

5: 15 percent / sodium acetate / ethanol; H₂O / 18 h / Heating

6: 1) m-chloroperbenzoic acid, 2) 10percent sodium sulphite / 1) dichloromethane, -78 deg C, 4 h, 2) ether, water, RT

With N-chloro-succinimide; dimethylsulfide; sodium acetate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium sulfite; In diethyl ether; ethanol; water; toluene;
DOI:10.1016/S0040-4020(01)96092-2