[(2R,3R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(4-nitro-benzyloxyoxalylsulfanyl)-4-oxo-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester

Base Information

• Chemical Name: [(2R,3R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(4-nitro-benzyloxyoxalylsulfanyl)-4-oxo-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester
• CAS No.: 87095-99-6
• Molecular Formula: C₄₇H₃₃N₄O₁₂PS
• Molecular Weight: 908.838

Synonyms:

Chemical Property of [(2R,3R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(4-nitro-benzyloxyoxalylsulfanyl)-4-oxo-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(2R,3R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(4-nitro-benzyloxyoxalylsulfanyl)-4-oxo-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester

There total 12 articles about [(2R,3R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(4-nitro-benzyloxyoxalylsulfanyl)-4-oxo-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,5R,6R)-benzyl 6-(1,3-dioxoisoindolin-2-yl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate (59034-26-3) → [(2R,3R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(4-nitro-benzyloxyoxalylsulfanyl)-4-oxo-azetidin-1-yl]-(triphenyl-λ5-phosphanylidene)-acetic acid 4-nitro-benzyl ester (87095-99-6)

Guidance literature:

Multi-step reaction with 9 steps

1: Rh₂(OAc)4 / benzene; CH₂Cl₂ / 16 h / Heating

2: Et₃N / CH₂Cl₂ / 2 h / 0 °C

3: 30 percent / p-toluenesulfonic acid / benzene / 48 h / Heating

4: 68 percent / KMnO₄ / dimethylformamide; pyridine; H₂O / 5 h / 0 °C

5: 79.5 percent / 3-Angstroem 1/16 molecular sieves / dimethylformamide; toluene / 24 h / Ambient temperature

6: 2,6-lutidine, thionyl chloride / tetrahydrofuran / 0.33 h / Ambient temperature

7: 2,6-lutidine / dioxane / 36 h / Ambient temperature

8: 79.6 percent / perchloric acid / CH₂Cl₂ / 0.67 h / Ambient temperature

With 2,6-dimethylpyridine; dirhodium tetraacetate; potassium permanganate; thionyl chloride; perchloric acid; 3 A molecular sieve; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; pyridine; dichloromethane; water; N,N-dimethyl-formamide; toluene; benzene;

DOI:10.1021/jo00355a011

Reference yield:

4-nitrobenzyl 2-diazo-3-oxo-butanoate (82551-63-1) → [(2R,3R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(4-nitro-benzyloxyoxalylsulfanyl)-4-oxo-azetidin-1-yl]-(triphenyl-λ5-phosphanylidene)-acetic acid 4-nitro-benzyl ester (87095-99-6)

Guidance literature:

Multi-step reaction with 9 steps

1: Rh₂(OAc)4 / benzene; CH₂Cl₂ / 16 h / Heating

2: Et₃N / CH₂Cl₂ / 2 h / 0 °C

3: 30 percent / p-toluenesulfonic acid / benzene / 48 h / Heating

4: 68 percent / KMnO₄ / dimethylformamide; pyridine; H₂O / 5 h / 0 °C

5: 79.5 percent / 3-Angstroem 1/16 molecular sieves / dimethylformamide; toluene / 24 h / Ambient temperature

6: 2,6-lutidine, thionyl chloride / tetrahydrofuran / 0.33 h / Ambient temperature

7: 2,6-lutidine / dioxane / 36 h / Ambient temperature

8: 79.6 percent / perchloric acid / CH₂Cl₂ / 0.67 h / Ambient temperature

With 2,6-dimethylpyridine; dirhodium tetraacetate; potassium permanganate; thionyl chloride; perchloric acid; 3 A molecular sieve; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; pyridine; dichloromethane; water; N,N-dimethyl-formamide; toluene; benzene;

DOI:10.1021/jo00355a011

Reference yield:

[(2R,3R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-oxo-azetidin-2-ylsulfanyl]-(2-methyl-[1,3]dioxolan-2-yl)-acetic acid 4-nitro-benzyl ester (87095-94-1,100163-36-8,100163-37-9) → [(2R,3R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(4-nitro-benzyloxyoxalylsulfanyl)-4-oxo-azetidin-1-yl]-(triphenyl-λ5-phosphanylidene)-acetic acid 4-nitro-benzyl ester (87095-99-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 79.5 percent / 3-Angstroem 1/16 molecular sieves / dimethylformamide; toluene / 24 h / Ambient temperature

2: 2,6-lutidine, thionyl chloride / tetrahydrofuran / 0.33 h / Ambient temperature

3: 2,6-lutidine / dioxane / 36 h / Ambient temperature

4: 79.6 percent / perchloric acid / CH₂Cl₂ / 0.67 h / Ambient temperature

With 2,6-dimethylpyridine; thionyl chloride; perchloric acid; 3 A molecular sieve; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jo00355a011

upstream raw materials:

(Z)-2-{(2R,3R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-1-[(4-nitro-benzyloxycarbonyl)-(triphenyl-λ⁵-phosphanylidene)-methyl]-4-oxo-azetidin-2-ylsulfanyl}-3-hydroxy-but-2-enoic acid 4-nitro-benzyl ester

(2S,5R,6R)-benzyl 6-(1,3-dioxoisoindolin-2-yl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

4-nitrobenzyl 2-diazo-3-oxo-butanoate

[(2R,3R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-oxo-azetidin-2-ylsulfanyl]-(2-methyl-[1,3]dioxolan-2-yl)-acetic acid 4-nitro-benzyl ester

Downstream raw materials:

(5R,6R)-6-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2,3-dicarboxylic acid bis-(4-nitro-benzyl) ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 87095-99-6 [(2R,3R)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(4-nitro-benzyloxyoxalylsulfanyl)-4-oxo-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send