C₁₅H₁₀F₂N₄O₂S

Base Information

• Chemical Name: C₁₅H₁₀F₂N₄O₂S
• CAS No.: 1276617-75-4
• Molecular Formula: C₁₅H₁₀F₂N₄O₂S
• Molecular Weight: 348.333
• Mol file: 1276617-75-4.mol

Synonyms:

Chemical Property of C₁₅H₁₀F₂N₄O₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₀F₂N₄O₂S

There total 4 articles about C₁₅H₁₀F₂N₄O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-fluoro-5-(pyrimidin-5-yloxy)benzonitrile (1276619-83-0) → C15H10F2N4O2S (1276617-75-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / water / 100 °C / Sealed tube

2: sulfuric acid / Reflux

3: potassium hexamethylsilazane / tetrahydrofuran

With sulfuric acid; potassium hexamethylsilazane; sodium hydroxide; In tetrahydrofuran; water;

DOI:10.1016/j.bmcl.2013.09.001

Reference yield:

3-fluoro-5-(pyrimidin-5-yloxy)benzoic acid (1276619-84-1) → C15H10F2N4O2S (1276617-75-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / Reflux

2: potassium hexamethylsilazane / tetrahydrofuran

With sulfuric acid; potassium hexamethylsilazane; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2013.09.001

Reference yield:

3,5-difluorobenzonitrile (64248-63-1) → C15H10F2N4O2S (1276617-75-4)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 150 °C

2: sodium hydroxide / water / 100 °C / Sealed tube

3: sulfuric acid / Reflux

4: potassium hexamethylsilazane / tetrahydrofuran

With sulfuric acid; potassium hexamethylsilazane; potassium carbonate; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.09.001

upstream raw materials:

5-fluoro-4-methylthiazol-2-amine

3-fluoro-5-(pyrimidin-5-yloxy)benzonitrile

3-fluoro-5-(pyrimidin-5-yloxy)benzoic acid

3,5-difluorobenzonitrile