Technology Process of 7-(4-Methoxy-benzyloxy)-3-methoxymethoxy-3-methyl-oct-5-ynal
There total 8 articles about 7-(4-Methoxy-benzyloxy)-3-methoxymethoxy-3-methyl-oct-5-ynal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: imidazole / dimethylformamide / 0.5 h
2: 19.9 g / NaH2PO4, m-chloroperoxybenzoic acid / CH2Cl2 / 1 h
4: diisopropylethylamine / CH2Cl2 / 0 - 20 °C
5: 10.2 g / tetrabutylammonium fluoride / tetrahydrofuran / 1 h
6: 1.) oxalyl chloride, DMSO, 2.) triethylamine / 1.) CH2Cl2, -78 deg C, 25 min, 2.) CH2Cl2, -78 deg C -> room temperature
With
1H-imidazole; sodium dihydrogenphosphate; oxalyl dichloride; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo970360d
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 19.9 g / NaH2PO4, m-chloroperoxybenzoic acid / CH2Cl2 / 1 h
3: diisopropylethylamine / CH2Cl2 / 0 - 20 °C
4: 10.2 g / tetrabutylammonium fluoride / tetrahydrofuran / 1 h
5: 1.) oxalyl chloride, DMSO, 2.) triethylamine / 1.) CH2Cl2, -78 deg C, 25 min, 2.) CH2Cl2, -78 deg C -> room temperature
With
sodium dihydrogenphosphate; oxalyl dichloride; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo970360d
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) NaH, 2.) Bu4NI / 1.) THF, 30 min, 2.) THF, room temperature, 2 d
3: diisopropylethylamine / CH2Cl2 / 0 - 20 °C
4: 10.2 g / tetrabutylammonium fluoride / tetrahydrofuran / 1 h
5: 1.) oxalyl chloride, DMSO, 2.) triethylamine / 1.) CH2Cl2, -78 deg C, 25 min, 2.) CH2Cl2, -78 deg C -> room temperature
With
oxalyl dichloride; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo970360d
