1-(3-benzyloxy-4-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidinemalonic acid

Base Information

Chemical Name:1-(3-benzyloxy-4-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidinemalonic acid
CAS No.:115262-57-2
Molecular Formula:C₂₆H₃₁NO₇
Molecular Weight:469.535
Hs Code.:

Synonyms:

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Chemical Property of 1-(3-benzyloxy-4-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidinemalonic acid

Chemical Property:

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Technology Process of 1-(3-benzyloxy-4-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidinemalonic acid

There total 22 articles about 1-(3-benzyloxy-4-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidinemalonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23428-78-6
4-[(3-benzyloxy-4-methoxy-phenyl)-thioacetyl]-morpholine

: 115262-57-2,118443-60-0
1-(3-benzyloxy-4-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidinemalonic acid

Guidance literature:: Multi-step reaction with 14 steps

1: 25.0 g / aq. KOH (50percent) / ethanol / 9 h / Heating

2: 94 percent / HCl / 17 h / 30 °C

3: 97 percent / LiAlH₄ / diethyl ether / 2 h / 0 - 20 °C

4: 93 percent / N-bromosuccinimide, triphenylphosphine (Ph₃P) / benzene / 5 h / 10 - 20 °C

5: 10.8 g / benzene / 96 h / Heating

6: 8.27 g / K₃Fe(CN)6, KOH / H₂O; benzene / 5 h / 32 °C

7: 97 percent / H₂ / Raney Ni W-2 / ethanol / 13 h / Ambient temperature

8: 96 percent / aq. HCl (10percent) / ethanol / 2 h / 50 °C

9: 84 percent / aq. hydrazine hydrate (80percent), KOH / ethane-1,2-diol / 1.) 120 deg C, 1 h; 2.) 190 deg C, 3.5 h

10: 97 percent / K₂CO₃ / acetone / 30 h / Heating

11: 77 percent / lithium diisopropylamide (LDA), hexamethylphosphoramide (HMPA) / tetrahydrofuran / 2 h / -78 °C

12: 1.17 g / sodium metaperiodate (NaIO₄) / methanol; H₂O / 24 h / Ambient temperature

13: 631 mg / CaCO₃ / toluene / 1 h / Heating

14: 1.) Na-EtOH; 2.) aq. NaOH (1N) / 1.) EtOH, 70 deg C, 2 h, reflux, 6 h; 2.) EtOH, 50 deg C, 4 h

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sodium hydroxide; sodium periodate; N-Bromosuccinimide; lithium aluminium tetrahydride; ethanol; hydrogen; sodium; potassium carbonate; hydrazine hydrate; triphenylphosphine; calcium carbonate; potassium hexacyanoferrate(III); lithium diisopropyl amide; Raney Ni W-2; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; ethylene glycol; acetone; toluene; benzene;

Reference yield:

: 55323-55-2
2-(5-(benzyloxy)-4-methoxyphenyl)-ethan-1-ol

: 115262-57-2,118443-60-0
1-(3-benzyloxy-4-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidinemalonic acid

Guidance literature:: Multi-step reaction with 11 steps

1: 93 percent / N-bromosuccinimide, triphenylphosphine (Ph₃P) / benzene / 5 h / 10 - 20 °C

2: 10.8 g / benzene / 96 h / Heating

3: 8.27 g / K₃Fe(CN)6, KOH / H₂O; benzene / 5 h / 32 °C

4: 97 percent / H₂ / Raney Ni W-2 / ethanol / 13 h / Ambient temperature

5: 96 percent / aq. HCl (10percent) / ethanol / 2 h / 50 °C

6: 84 percent / aq. hydrazine hydrate (80percent), KOH / ethane-1,2-diol / 1.) 120 deg C, 1 h; 2.) 190 deg C, 3.5 h

7: 97 percent / K₂CO₃ / acetone / 30 h / Heating

8: 77 percent / lithium diisopropylamide (LDA), hexamethylphosphoramide (HMPA) / tetrahydrofuran / 2 h / -78 °C

9: 1.17 g / sodium metaperiodate (NaIO₄) / methanol; H₂O / 24 h / Ambient temperature

10: 631 mg / CaCO₃ / toluene / 1 h / Heating

11: 1.) Na-EtOH; 2.) aq. NaOH (1N) / 1.) EtOH, 70 deg C, 2 h, reflux, 6 h; 2.) EtOH, 50 deg C, 4 h

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sodium hydroxide; sodium periodate; N-Bromosuccinimide; ethanol; hydrogen; sodium; potassium carbonate; hydrazine hydrate; triphenylphosphine; calcium carbonate; potassium hexacyanoferrate(III); lithium diisopropyl amide; Raney Ni W-2; In tetrahydrofuran; methanol; ethanol; water; ethylene glycol; acetone; toluene; benzene;

Reference yield:

: 5487-33-2
O-benzylhomoisovanillic acid

: 115262-57-2,118443-60-0
1-(3-benzyloxy-4-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidinemalonic acid

Guidance literature:: Multi-step reaction with 13 steps

1: 94 percent / HCl / 17 h / 30 °C

2: 97 percent / LiAlH₄ / diethyl ether / 2 h / 0 - 20 °C

3: 93 percent / N-bromosuccinimide, triphenylphosphine (Ph₃P) / benzene / 5 h / 10 - 20 °C

4: 10.8 g / benzene / 96 h / Heating

5: 8.27 g / K₃Fe(CN)6, KOH / H₂O; benzene / 5 h / 32 °C

6: 97 percent / H₂ / Raney Ni W-2 / ethanol / 13 h / Ambient temperature

7: 96 percent / aq. HCl (10percent) / ethanol / 2 h / 50 °C

8: 84 percent / aq. hydrazine hydrate (80percent), KOH / ethane-1,2-diol / 1.) 120 deg C, 1 h; 2.) 190 deg C, 3.5 h

9: 97 percent / K₂CO₃ / acetone / 30 h / Heating

10: 77 percent / lithium diisopropylamide (LDA), hexamethylphosphoramide (HMPA) / tetrahydrofuran / 2 h / -78 °C

11: 1.17 g / sodium metaperiodate (NaIO₄) / methanol; H₂O / 24 h / Ambient temperature

12: 631 mg / CaCO₃ / toluene / 1 h / Heating

13: 1.) Na-EtOH; 2.) aq. NaOH (1N) / 1.) EtOH, 70 deg C, 2 h, reflux, 6 h; 2.) EtOH, 50 deg C, 4 h

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sodium hydroxide; sodium periodate; N-Bromosuccinimide; lithium aluminium tetrahydride; ethanol; hydrogen; sodium; potassium carbonate; hydrazine hydrate; triphenylphosphine; calcium carbonate; potassium hexacyanoferrate(III); lithium diisopropyl amide; Raney Ni W-2; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; ethylene glycol; acetone; toluene; benzene;