Technology Process of (R)-1-((2R,3S,4S,5R,6S)-3,4,5-Tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-yl)-2-trityloxy-ethanol
There total 12 articles about (R)-1-((2R,3S,4S,5R,6S)-3,4,5-Tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-yl)-2-trityloxy-ethanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: H2 / Lindlar catalyst / toluene / Ambient temperature
2: 1.) O3, 2.) Ph3P / 1.) CH2Cl2, -78 deg C, 24 min, 2.) CH2Cl2, 0 deg C, 1 h
3: lithium aluminum hydride / tetrahydrofuran / 1 h / Ambient temperature
4: pyridine / benzene / 3 h / Heating
5: pyridine / benzene / 24 h / Ambient temperature
6: dimethylformamide / 2 h / Heating
7: K2CO3, methanol / Ambient temperature
With
pyridine; methanol; lithium aluminium tetrahydride; hydrogen; potassium carbonate; ozone; triphenylphosphine;
Lindlar's catalyst;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene; benzene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: H2 / Lindlar catalyst / toluene / Ambient temperature
2: 1.) O3, 2.) Ph3P / 1.) CH2Cl2, -78 deg C, 24 min, 2.) CH2Cl2, 0 deg C, 1 h
3: lithium aluminum hydride / tetrahydrofuran / 1 h / Ambient temperature
4: pyridine / benzene / 3 h / Heating
With
pyridine; lithium aluminium tetrahydride; hydrogen; ozone; triphenylphosphine;
Lindlar's catalyst;
In
tetrahydrofuran; toluene; benzene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: pyridine / benzene / 3 h / Heating
2: pyridine / benzene / 24 h / Ambient temperature
3: dimethylformamide / 2 h / Heating
4: K2CO3, methanol / Ambient temperature
With
pyridine; methanol; potassium carbonate;
In
N,N-dimethyl-formamide; benzene;
