<(2R,3S)+(2S,3R)>-N-(carbobenzyloxy)-N-methyl-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<3-(1,1,1-trifluoro-4-methyl-2-hydroxypentyl)>amide

Base Information

Chemical Name:<(2R,3S)+(2S,3R)>-N-(carbobenzyloxy)-N-methyl-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<3-(1,1,1-trifluoro-4-methyl-2-hydroxypentyl)>amide
CAS No.:137301-82-7
Molecular Formula:C₃₁H₄₀F₃N₃O₅
Molecular Weight:591.671
Hs Code.:

<(2R,3S)+(2S,3R)>-N-(carbobenzyloxy)-N-methyl-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<3-(1,1,1-trifluoro-4-methyl-2-hydroxypentyl)>amide

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Chemical Property of <(2R,3S)+(2S,3R)>-N-(carbobenzyloxy)-N-methyl-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<3-(1,1,1-trifluoro-4-methyl-2-hydroxypentyl)>amide

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Technology Process of <(2R,3S)+(2S,3R)>-N-(carbobenzyloxy)-N-methyl-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<3-(1,1,1-trifluoro-4-methyl-2-hydroxypentyl)>amide

There total 6 articles about <(2R,3S)+(2S,3R)>-N-(carbobenzyloxy)-N-methyl-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<3-(1,1,1-trifluoro-4-methyl-2-hydroxypentyl)>amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 137301-81-6
{[(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-methyl-butyryl]-indan-2-yl-amino}-acetic acid

: 136182-45-1
<(2R,3S)+(2S,3R)>-3-amino-4-methyl-1,1,1-trifluoro-2-pentanol

: 137301-82-7,137429-38-0
<(2R,3S)+(2S,3R)>-N-(carbobenzyloxy)-N-methyl-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<3-(1,1,1-trifluoro-4-methyl-2-hydroxypentyl)>amide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 - 20 ℃; for 4.5h;
DOI:10.1021/jm00082a005

Reference yield:

: 42417-65-2
Z-MeVal-OH

: 137301-82-7,137429-38-0
<(2R,3S)+(2S,3R)>-N-(carbobenzyloxy)-N-methyl-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<3-(1,1,1-trifluoro-4-methyl-2-hydroxypentyl)>amide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) diethyl chlorophosphate, Et₃N / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) CH₂Cl₂, a) 0 deg C, 1 h, b) RT, 18 h

2: 96 percent / 1 N aq. KOH / ethanol / 16 h / Ambient temperature

3: 100 percent / HOBT, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (WSCDI) / tetrahydrofuran / 4.5 h / 0 - 20 °C

With potassium hydroxide; benzotriazol-1-ol; diethyl chlorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00082a005

Reference yield:

: (S)-2-(Benzyloxycarbonyl-methyl-amino)-3-methyl-butyric acid ethyl ester

: 137301-82-7,137429-38-0
<(2R,3S)+(2S,3R)>-N-(carbobenzyloxy)-N-methyl-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<3-(1,1,1-trifluoro-4-methyl-2-hydroxypentyl)>amide

Guidance literature:: Multi-step reaction with 4 steps

1: 1 N NaOH / ethanol / 16 h / Ambient temperature

2: 1.) diethyl chlorophosphate, Et₃N / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) CH₂Cl₂, a) 0 deg C, 1 h, b) RT, 18 h

3: 96 percent / 1 N aq. KOH / ethanol / 16 h / Ambient temperature

4: 100 percent / HOBT, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (WSCDI) / tetrahydrofuran / 4.5 h / 0 - 20 °C

With potassium hydroxide; sodium hydroxide; benzotriazol-1-ol; diethyl chlorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00082a005