(1beta,3alpha,4beta,9S)-6'-Methoxycinchonan-9-ol

Base Information

• Chemical Name: (1beta,3alpha,4beta,9S)-6'-Methoxycinchonan-9-ol
• CAS No.: 42151-59-7
• Molecular Formula: C₂₀H₂₄N₂O₂
• Molecular Weight: 324.423
• DSSTox Substance ID: DTXSID701282498
• ChEMBL ID: CHEMBL460606

Synonyms:Conchinin;Quinidex;quinidin-;Chinidin [German];42151-59-7;C20H24N2O2;NCI-C56246;NSC 5362;Cinchonan-9-ol, 6'-methoxy-, (8alpha,9R)-;Cinchonan-9-ol, 6'-methoxy-, (8.alpha.,9R)-;CHEMBL460606;SCHEMBL6351954;DTXSID701282498;NCGC00142453-01;EN300-26906222;(1beta,3alpha,4beta,9S)-6'-Methoxycinchonan-9-ol;(S)-[(2R,4R,5S)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol

Chemical Property of (1beta,3alpha,4beta,9S)-6'-Methoxycinchonan-9-ol

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 324.183778013
• Heavy Atom Count: 24
• Complexity: 457

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O
• Isomeric SMILES: COC1=CC2=C(C=CN=C2C=C1)[C@@H]([C@H]3C[C@H]4CCN3C[C@H]4C=C)O

Technology Process of (1beta,3alpha,4beta,9S)-6'-Methoxycinchonan-9-ol

There total 107 articles about (1beta,3alpha,4beta,9S)-6'-Methoxycinchonan-9-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

quinidine acetate (56652-53-0) → quinindine (56-54-2,130-95-0,572-59-8,572-60-1,42151-59-7,47342-58-5,72402-50-7,72402-51-8,72402-52-9,72402-53-0,101143-86-6,101143-87-7,101143-88-8,146925-10-2)

Guidance literature:

With methanol; potassium carbonate; at 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.12.066

Reference yield: 75.0%

(3R,4S)-4-[(2S,3S)-3-(6-Methoxy-quinolin-4-yl)-oxiranylmethyl]-3-vinyl-piperidine-1-carboxylic acid 2-trimethylsilanyl-ethyl ester (865853-19-6) → quinindine (56-54-2,130-95-0,572-59-8,572-60-1,42151-59-7,47342-58-5,72402-50-7,72402-51-8,72402-52-9,72402-53-0,101143-86-6,101143-87-7,101143-88-8,146925-10-2)

Guidance literature:

With cesium fluoride;

DOI:10.1016/j.tetlet.2005.06.171

Reference yield:

6-Methoxy-4-[(2S,3S)-3-((3R,4S)-3-vinyl-piperidin-4-ylmethyl)-oxiranyl]-quinoline → quinindine (56-54-2,130-95-0,572-59-8,572-60-1,42151-59-7,47342-58-5,72402-50-7,72402-51-8,72402-52-9,72402-53-0,101143-86-6,101143-87-7,101143-88-8,146925-10-2)

Guidance literature:

In acetonitrile; at 185 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1021/ja039550y

upstream raw materials:

quinidine

Quinine

O-tosylquinine

water

Downstream raw materials:

(S)-(6-Methoxy-quinolin-4-yl)-((1S,2S,4S,5R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol; compound with [benzyl-(2-oxo-2H-quinolin-1-yl)-amino]-acetic acid

6'-methoxycinchonidone

6'-methoxycinchoninone

viquidil

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 42151-59-7 (6-Methoxy-quinolin-4-yl)-((1S,2S,4S,5R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol

Send

Send

Metric Ton KG G Pound L ML

Send

Send