rac-<2R,3S(R)>-2-<3-<<<4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)piperazinyl>carbonyl>oxy>-2-oxopropyl>-3-<1-<(trimethylsilyl)oxy>ethyl>-4-oxo-α-(triphenylphosphoranylidene)azetidine-1-acetic acid (2,2-dimethyl-1-oxopropoxy)...

Base Information

• Chemical Name: rac-<2R,3S(R)>-2-<3-<<<4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)piperazinyl>carbonyl>oxy>-2-oxopropyl>-3-<1-<(trimethylsilyl)oxy>ethyl>-4-oxo-α-(triphenylphosphoranylidene)azetidine-1-acetic acid (2,2-dimethyl-1-oxopropoxy)...
• CAS No.: 141017-66-5
• Molecular Formula: C₅₅H₆₂FN₄O₁₂PSi
• Molecular Weight: 1049.17

Synonyms:

Chemical Property of rac-<2R,3S(R)>-2-<3-<<<4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)piperazinyl>carbonyl>oxy>-2-oxopropyl>-3-<1-<(trimethylsilyl)oxy>ethyl>-4-oxo-α-(triphenylphosphoranylidene)azetidine-1-acetic acid (2,2-dimethyl-1-oxopropoxy)...

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-<2R,3S(R)>-2-<3-<<<4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)piperazinyl>carbonyl>oxy>-2-oxopropyl>-3-<1-<(trimethylsilyl)oxy>ethyl>-4-oxo-α-(triphenylphosphoranylidene)azetidine-1-acetic acid (2,2-dimethyl-1-oxopropoxy)...

There total 7 articles about rac-<2R,3S(R)>-2-<3-<<<4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)piperazinyl>carbonyl>oxy>-2-oxopropyl>-3-<1-<(trimethylsilyl)oxy>ethyl>-4-oxo-α-(triphenylphosphoranylidene)azetidine-1-acetic acid (2,2-dimethyl-1-oxopropoxy)... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ciprofloxacin (85721-33-1,178489-05-9,189257-90-7) → rac-<2R,3S(R)>-2-<3-<<<4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)piperazinyl>carbonyl>oxy>-2-oxopropyl>-3-<1-<(trimethylsilyl)oxy>ethyl>-4-oxo-α-(triphenylphosphoranylidene)azetidine-1-acetic acid (2,2-dimethyl-1-oxopropoxy)... (141017-66-5)

Guidance literature:

Multi-step reaction with 4 steps

1: CH₂Cl₂ / 0.67 h / Ambient temperature

2: CH₂Cl₂ / 1.83 h / 0 - 20 °C / a) 0 deg C, 35 min, b) RT, 75 min

3: 75 percent / 90percent aq. CH₃COOH, Zn / 0.75 h / Ambient temperature

4: pyridine / 5.5 h / Ambient temperature

With pyridine; acetic acid; zinc; In dichloromethane;

DOI:10.1021/jm00088a019

Reference yield:

N,O-bis(trimethylsilyl)ciprofloxacin → rac-<2R,3S(R)>-2-<3-<<<4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)piperazinyl>carbonyl>oxy>-2-oxopropyl>-3-<1-<(trimethylsilyl)oxy>ethyl>-4-oxo-α-(triphenylphosphoranylidene)azetidine-1-acetic acid (2,2-dimethyl-1-oxopropoxy)... (141017-66-5)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂ / 1.83 h / 0 - 20 °C / a) 0 deg C, 35 min, b) RT, 75 min

2: 75 percent / 90percent aq. CH₃COOH, Zn / 0.75 h / Ambient temperature

3: pyridine / 5.5 h / Ambient temperature

With pyridine; acetic acid; zinc; In dichloromethane;

DOI:10.1021/jm00088a019

Reference yield:

rac-<2R,3S(R)>-2-(3-hydroxy-2-oxopropyl)-3-<1-<<(2,2,2-trichloroethoxy)carbonyl>oxy>ethyl>-4-oxo-α-(triphenylphosphoranylidene)azetidine-1-acetic acid (2,2-dimethyl-1-oxopropoxy)methyl ester (138423-48-0) → rac-<2R,3S(R)>-2-<3-<<<4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)piperazinyl>carbonyl>oxy>-2-oxopropyl>-3-<1-<(trimethylsilyl)oxy>ethyl>-4-oxo-α-(triphenylphosphoranylidene)azetidine-1-acetic acid (2,2-dimethyl-1-oxopropoxy)... (141017-66-5)

Guidance literature:

Multi-step reaction with 4 steps

1: N,N-diisopropylethylamine / toluene; CH₂Cl₂ / a) 0 deg C, 30 min, b) RT, 45 min

2: CH₂Cl₂ / 1.83 h / 0 - 20 °C / a) 0 deg C, 35 min, b) RT, 75 min

3: 75 percent / 90percent aq. CH₃COOH, Zn / 0.75 h / Ambient temperature

4: pyridine / 5.5 h / Ambient temperature

With pyridine; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In dichloromethane; toluene;

DOI:10.1021/jm00088a019

upstream raw materials:

ciprofloxacin

rac-<2R,3S(R)>-2-(3-hydroxy-2-oxopropyl)-3-<1-<<(2,2,2-trichloroethoxy)carbonyl>oxy>ethyl>-4-oxo-α-(triphenylphosphoranylidene)azetidine-1-acetic acid (2,2-dimethyl-1-oxopropoxy)methyl ester

rac-<2R,3S(R)>-2-(3-bromo-2-oxopropyl)-3-<1-<<(2,2,2-trichloroethoxy)carbonyl>oxy>ethyl>-4-oxo-α-(triphenylphosphoranylidene)azetidine-1-acetic acid (2,2-dimethyl-1-oxopropoxy)methyl ester

rac-<2R,3S(R)>-2-<3-<(chloroacetyl)oxy>-2-oxopropyl>-3-<1-<<(2,2,2-trichloroethoxy)carbonyl>oxy>ethyl>-4-oxo-α-(triphenylphosphoranylidene)azetidine-1-acetic acid (2,2-dimethyl-1-oxopropoxy)methyl ester

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