(S)-N-((S)-1-Carboxy-2-phenyl-ethyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-(6-hydroxy-benzo[1,3]oxathiol-5-ylmethyl)-succinamic acid tert-butyl ester

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Chemical Name:(S)-N-((S)-1-Carboxy-2-phenyl-ethyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-(6-hydroxy-benzo[1,3]oxathiol-5-ylmethyl)-succinamic acid tert-butyl ester
CAS No.:201285-56-5
Molecular Formula:C₄₀H₄₀N₂O₉S
Molecular Weight:724.832
Hs Code.:

(S)-N-((S)-1-Carboxy-2-phenyl-ethyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-(6-hydroxy-benzo[1,3]oxathiol-5-ylmethyl)-succinamic acid tert-butyl ester

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Chemical Property of (S)-N-((S)-1-Carboxy-2-phenyl-ethyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-(6-hydroxy-benzo[1,3]oxathiol-5-ylmethyl)-succinamic acid tert-butyl ester

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Technology Process of (S)-N-((S)-1-Carboxy-2-phenyl-ethyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-(6-hydroxy-benzo[1,3]oxathiol-5-ylmethyl)-succinamic acid tert-butyl ester

There total 6 articles about (S)-N-((S)-1-Carboxy-2-phenyl-ethyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-(6-hydroxy-benzo[1,3]oxathiol-5-ylmethyl)-succinamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4991-65-5
tioxolone

: 201285-56-5
(S)-N-((S)-1-Carboxy-2-phenyl-ethyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-(6-hydroxy-benzo[1,3]oxathiol-5-ylmethyl)-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: BF₃*Et₂O / tetrahydrofuran / 0.25 h / Ambient temperature

2: 70 percent / K₂CO₃, CH₂Br₂ / butan-2-one / 48 h / Heating

3: POCl₃ / 1,2-dichloro-ethane / 12 h / from 0 deg C to RT

4: KOH, NaBH₄ / H₂O; ethanol / 0.25 h / Ambient temperature

5: Na₂CO₃ / H₂O; dioxane

With potassium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; sodium carbonate; potassium carbonate; trichlorophosphate; 1,1-dibromomethane; In tetrahydrofuran; 1,4-dioxane; ethanol; water; 1,2-dichloro-ethane; butanone;
DOI:10.1016/S0040-4039(97)10431-2

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 201285-56-5
(S)-N-((S)-1-Carboxy-2-phenyl-ethyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-(6-hydroxy-benzo[1,3]oxathiol-5-ylmethyl)-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: KOH, NaBH₄ / H₂O; ethanol / 0.25 h / Ambient temperature

2: Na₂CO₃ / H₂O; dioxane

With potassium hydroxide; sodium tetrahydroborate; sodium carbonate; In 1,4-dioxane; ethanol; water;
DOI:10.1016/S0040-4039(97)10431-2

Reference yield:

: 201285-50-9
6-tert-butoxy-1,3-benzoxathiole

: 201285-56-5
(S)-N-((S)-1-Carboxy-2-phenyl-ethyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-(6-hydroxy-benzo[1,3]oxathiol-5-ylmethyl)-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: POCl₃ / 1,2-dichloro-ethane / 12 h / from 0 deg C to RT

2: KOH, NaBH₄ / H₂O; ethanol / 0.25 h / Ambient temperature

3: Na₂CO₃ / H₂O; dioxane

With potassium hydroxide; sodium tetrahydroborate; sodium carbonate; trichlorophosphate; In 1,4-dioxane; ethanol; water; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4039(97)10431-2