Phenyl-[(5aS,6aR,7aS)-7-((S)-1-phenyl-ethyl)-5,5a,6,6a,7,7a-hexahydro-4,7-diaza-cyclopropa[e]acenaphthylen-4-yl]-methanone

Base Information

• Chemical Name: Phenyl-[(5aS,6aR,7aS)-7-((S)-1-phenyl-ethyl)-5,5a,6,6a,7,7a-hexahydro-4,7-diaza-cyclopropa[e]acenaphthylen-4-yl]-methanone
• CAS No.: 132557-13-2
• Molecular Formula: C₂₆H₂₄N₂O
• Molecular Weight: 380.489
• Mol file: 132557-13-2.mol

Synonyms:

Chemical Property of Phenyl-[(5aS,6aR,7aS)-7-((S)-1-phenyl-ethyl)-5,5a,6,6a,7,7a-hexahydro-4,7-diaza-cyclopropa[e]acenaphthylen-4-yl]-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenyl-[(5aS,6aR,7aS)-7-((S)-1-phenyl-ethyl)-5,5a,6,6a,7,7a-hexahydro-4,7-diaza-cyclopropa[e]acenaphthylen-4-yl]-methanone

There total 10 articles about Phenyl-[(5aS,6aR,7aS)-7-((S)-1-phenyl-ethyl)-5,5a,6,6a,7,7a-hexahydro-4,7-diaza-cyclopropa[e]acenaphthylen-4-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

[(2aR,4R,5R)-4-Hydroxy-5-((S)-1-phenyl-ethylamino)-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl]-phenyl-methanone (132557-12-1) → Phenyl-[(5aR,6aS,7aR)-7-((S)-1-phenyl-ethyl)-5,5a,6,6a,7,7a-hexahydro-4,7-diaza-cyclopropa[e]acenaphthylen-4-yl]-methanone (132557-13-2,132619-32-0,141434-26-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; or with Br₂/Ph₃P;

DOI:10.1016/S0040-4039(00)97303-9

Reference yield: 84.5%

[(2aR,4R,5R)-4-Hydroxy-5-((S)-1-phenyl-ethylamino)-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl]-phenyl-methanone (132557-12-1) → Phenyl-[(5aS,6aR,7aS)-7-((S)-1-phenyl-ethyl)-5,5a,6,6a,7,7a-hexahydro-4,7-diaza-cyclopropa[e]acenaphthylen-4-yl]-methanone (132557-13-2,132619-32-0,141434-26-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jo971256z

Reference yield:

[(2aS,4S,5S)-4-Hydroxy-5-((S)-1-phenyl-ethylamino)-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl]-phenyl-methanone (132619-31-9) → Phenyl-[(5aS,6aR,7aS)-7-((S)-1-phenyl-ethyl)-5,5a,6,6a,7,7a-hexahydro-4,7-diaza-cyclopropa[e]acenaphthylen-4-yl]-methanone (132557-13-2,132619-32-0,141434-26-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; Yield given; or with Br₂/Ph₃P;

DOI:10.1016/S0040-4039(00)97303-9

upstream raw materials:

[(2aR,4R,5R)-4-Hydroxy-5-((S)-1-phenyl-ethylamino)-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl]-phenyl-methanone

(S)-1-phenyl-ethylamine

Phenyl-(5aS,6aS,7aR)-5a,6,6a,7a-tetrahydro-5H-7-oxa-4-aza-cyclopropa[e]acenaphthylen-4-yl-methanone

[(2aR,4R,5R)-6-Bromo-4-hydroxy-5-((S)-1-phenyl-ethylamino)-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl]-phenyl-methanone

Downstream raw materials:

(+)-1-Benzoyl-1,2,2a,3,4,5-hexahydrobenzindol-4-amine

(-)-1-Benzoyl-1,2,2a,3,4,5-hexahydrobenzindol-4-amine

(+) (2aR,4S)-1-benzoyl-6-iodo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole

((2aR,4S)-4-Amino-6-iodo-2a,3,4,5-tetrahydro-2H-benzo[cd]indol-1-yl)-phenyl-methanone