1-((2R,3R,3aR,9aR)-3-Allyloxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-4-(2,5-dimethyl-phenoxy)-1H-pyrimidin-2-one

Base Information

Chemical Name:1-((2R,3R,3aR,9aR)-3-Allyloxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-4-(2,5-dimethyl-phenoxy)-1H-pyrimidin-2-one
CAS No.:144640-89-1
Molecular Formula:C₃₂H₅₀N₂O₇Si₂
Molecular Weight:630.929
Hs Code.:

1-((2R,3R,3aR,9aR)-3-Allyloxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-4-(2,5-dimethyl-phenoxy)-1H-pyrimidin-2-one

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Chemical Property of 1-((2R,3R,3aR,9aR)-3-Allyloxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-4-(2,5-dimethyl-phenoxy)-1H-pyrimidin-2-one

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Technology Process of 1-((2R,3R,3aR,9aR)-3-Allyloxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-4-(2,5-dimethyl-phenoxy)-1H-pyrimidin-2-one

There total 6 articles about 1-((2R,3R,3aR,9aR)-3-Allyloxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-4-(2,5-dimethyl-phenoxy)-1H-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1469-70-1
allyl ethyl carbonate

: 144640-88-0
4-(2,5-Dimethyl-phenoxy)-1-((2R,3R,3aS,9aR)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidin-2-one

: 144640-89-1
1-((2R,3R,3aR,9aR)-3-Allyloxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-4-(2,5-dimethyl-phenoxy)-1H-pyrimidin-2-one

Guidance literature:: With (dibenzylideneacetone)palladium; triphenylphosphine; In tetrahydrofuran; at 60 - 65 ℃; for 2h; Yield given;
DOI:10.1246/bcsj.65.1665

Reference yield:

: 95-87-4
2,5-Dimethylphenol

: 144640-89-1
1-((2R,3R,3aR,9aR)-3-Allyloxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-4-(2,5-dimethyl-phenoxy)-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: TEA, DABCO

2: NH₃ / methanol / 0.5 h / 30 °C

3: palladium dibenzylideneacetone, Ph₃P / tetrahydrofuran / 2 h / 60 - 65 °C

With 1,4-diaza-bicyclo[2.2.2]octane; (dibenzylideneacetone)palladium; TEA; ammonia; triphenylphosphine; In tetrahydrofuran; methanol;
DOI:10.1246/bcsj.65.1665

Reference yield:

: Acetic acid (2R,3R,3aR,9aR)-2-[4-(2,5-dimethyl-phenoxy)-2-oxo-2H-pyrimidin-1-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester

: 144640-89-1
1-((2R,3R,3aR,9aR)-3-Allyloxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-4-(2,5-dimethyl-phenoxy)-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: NH₃ / methanol / 0.5 h / 30 °C

2: palladium dibenzylideneacetone, Ph₃P / tetrahydrofuran / 2 h / 60 - 65 °C

With palladium dibenzylideneacetone; ammonia; triphenylphosphine; In tetrahydrofuran; methanol;
DOI:10.1246/bcsj.65.1665