1,2',6'-tris-4->-7'-(3-hydroxypropyl)-6'-epifortimicin B

Base Information

Chemical Name:1,2',6'-tris-4->-7'-(3-hydroxypropyl)-6'-epifortimicin B
CAS No.:116144-46-8
Molecular Formula:C₅₂H₆₅N₅O₁₅
Molecular Weight:1000.11
Hs Code.:

1,2',6'-tris<N-(benzyloxycarbonyl)>-4-<N-<N-(benzyloxycarbonyl)glycyl>>-7'-(3-hydroxypropyl)-6'-epifortimicin B

Synonyms:

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Chemical Property of 1,2',6'-tris-4->-7'-(3-hydroxypropyl)-6'-epifortimicin B

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1,2',6'-tris-4->-7'-(3-hydroxypropyl)-6'-epifortimicin B

There total 14 articles about 1,2',6'-tris-4->-7'-(3-hydroxypropyl)-6'-epifortimicin B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 2899-60-7
Cbz-Gly-ONSuc

: 116144-45-7,116184-06-6
1,2',6'-tris-7'-(3-hydroxypropyl)-6'-epifortimicin B

: 116144-46-8,116184-07-7
1,2',6'-tris-4->-7'-(3-hydroxypropyl)-6'-epifortimicin B

Guidance literature:: With triethylamine; In 1,4-dioxane; at 60 ℃; for 18h;
DOI:10.1016/0008-6215(87)85004-8

Reference yield: 60.0%

: 2899-60-7
Cbz-Gly-ONSuc

: 116144-45-7,116184-06-6
1,2',6'-tris-7'-(3-hydroxypropyl)fortimicin B

: 116144-46-8,116184-07-7
1,2',6'-tris-4->-7'-(3-hydroxypropyl)fortimicin B

Guidance literature:: With triethylamine; In 1,4-dioxane; at 45 ℃; for 22h;
DOI:10.1016/0008-6215(87)85004-8

Reference yield:

: 116144-34-4,116184-09-9
methyl 2-acetamido-2,3,4,6,7,8,9-heptadeoxy-10-O-(tetrahydropyranyl)-6-nitro-β-L-lyxo-and-α-D-ribo-decopyranoside

: 116144-46-8,116184-07-7
1,2',6'-tris-4->-7'-(3-hydroxypropyl)fortimicin B

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) hydrogen / 1.) Raney nickel / 1.) methanol, 345 kPa, 18 h; 2.) methanol

2: boron trifluoride etherate / 1.) dichloromethane-methanol-ether, 2 h; 2.) pyridine, 1 h

3: 1.) 2 M hydrochloric acid; 2.) triethylamine / 1.) water, reflux, 3 h; 2.) methanol, 12 h; 3.) pyridine, 11 h

4: 35 percent / powdered molecular sieve 4A, trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 4 h / Ambient temperature

5: 44 percent / 1.) barium hydroxide octahydrate; 2.) Amberlite IRA-400(OH^-) / dioxane; H₂O / 8.5 h / Heating

6: 52 percent / methanol; H₂O / 1.) 0 deg C, 1.5 h; 2.) roomtemp., 18 h

7: 60 percent / triethylamine / dioxane / 22 h / 45 °C

With hydrogenchloride; barium hydroxide octahydrate; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; Amberlite IRA-400(OH^-); boron trifluoride diethyl etherate; hydrogen; triethylamine; nickel; In 1,4-dioxane; methanol; water; 1,2-dichloro-ethane;
DOI:10.1016/0008-6215(87)85004-8