o-(methylamino)phenyl sec-butyl ketone

Base Information

• Chemical Name: o-(methylamino)phenyl sec-butyl ketone
• CAS No.: 154010-88-5
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.273
• Mol file: 154010-88-5.mol

Synonyms:

Chemical Property of o-(methylamino)phenyl sec-butyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of o-(methylamino)phenyl sec-butyl ketone

There total 1 articles about o-(methylamino)phenyl sec-butyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylaminobenzonitrile (17583-40-3) + sec.-butyllithium (598-30-1) → o-(methylamino)phenyl sec-butyl ketone (154010-88-5)

Guidance literature:

With hydrogenchloride; Yield given. Multistep reaction; 1.) cyclohexane, Et₂O, 0 deg C, 5 h, 2.) H₂O, room temperature, 0.5 h;

DOI:10.1039/P19930002463

Reference yield:

o-(methylamino)phenyl sec-butyl ketone (154010-88-5) → 2-diphenylphosphinoyl-1-methyl-3-(1-methylpropyl)indole

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) EtOH, 3.) K₂CO₃ / 1.) toluene, reflux, overnight, 2.) THF, room temperature, 1 h, 3.) 15 min

2: 70 percent / BuLi, diisopropylamine / hexane; tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) -78 deg C, 0.5 h

With n-butyllithium; ethanol; potassium carbonate; diisopropylamine; In tetrahydrofuran; hexane;

DOI:10.1039/P19930002463

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + chloro-diphenylphosphine (1079-66-9,74391-44-9) + o-(methylamino)phenyl sec-butyl ketone (154010-88-5) → o-phenyl sec-butyl ketone (154010-83-0)

Guidance literature:

With ethanol; potassium carbonate; Yield given. Multistep reaction; 1.) toluene, reflux, overnight, 2.) THF, room temperature, 1 h, 3.) 15 min;

DOI:10.1039/P19930002463

upstream raw materials:

2-methylaminobenzonitrile

sec.-butyllithium

Downstream raw materials:

o-phenyl sec-butyl ketone