tert-butyl 2-(3-amino-1H-pyrazol-1-yl)acetate

Base Information

• Chemical Name: tert-butyl 2-(3-amino-1H-pyrazol-1-yl)acetate
• CAS No.: 1003011-06-0
• Molecular Formula: C₉H₁₅N₃O₂
• Molecular Weight: 197.237
• Mol file: 1003011-06-0.mol

Synonyms:

Chemical Property of tert-butyl 2-(3-amino-1H-pyrazol-1-yl)acetate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(3-Amino-pyrazol-1-yl)-aceticacidtert-butylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(3-amino-1H-pyrazol-1-yl)acetate

There total 4 articles about tert-butyl 2-(3-amino-1H-pyrazol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(3-nitro-pyrazol-1-yl)-acetic acid tert-butyl ester (1003011-05-9) → tert-butyl 2-(3-amino-1H-pyrazol-1-yl)acetate (1003011-06-0)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 25 ℃; for 16h;

Reference yield: 38.6%

3-aminopyrazole (1820-80-0,916420-28-5) + bromoacetic acid tert-butyl ester (5292-43-3) → tert-butyl 2-(3-amino-1H-pyrazol-1-yl)acetate (1003011-06-0)

Guidance literature:

3-aminopyrazole; With potassium tert-butylate; In N,N-dimethyl-formamide; at 0 ℃; for 0.666667h;

bromoacetic acid tert-butyl ester; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.16667h;

Reference yield:

[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pyrazol-1-yl]-acetic acid tert-butyl ester (1364925-25-6) → tert-butyl 2-(3-amino-1H-pyrazol-1-yl)acetate (1003011-06-0)

Guidance literature:

With hydrazine; In ethanol; at 90 ℃; for 2.5h;

upstream raw materials:

(3-nitro-pyrazol-1-yl)-acetic acid tert-butyl ester

[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pyrazol-1-yl]-acetic acid tert-butyl ester

bromoacetic acid tert-butyl ester

3-aminopyrazole

Downstream raw materials:

[3-(3-benzoyl-thioureido)-pyrazol-1-yl]-acetic acid tert-butyl ester

Refernces

• 1、 -. "Pyrazole glucokinase activators". Page/Page column 26. . Retrieved 2008/06/13.