(R)-N-tert-butoxycarbonyl-4,4-difluoro-3,3-dimethylproline methyl ester

Base Information

Chemical Name:(R)-N-tert-butoxycarbonyl-4,4-difluoro-3,3-dimethylproline methyl ester
CAS No.:854375-31-8
Molecular Formula:C₁₃H₂₁F₂NO₄
Molecular Weight:293.311
Hs Code.:

Synonyms:

Suppliers and Price of (R)-N-tert-butoxycarbonyl-4,4-difluoro-3,3-dimethylproline methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-N-tert-butoxycarbonyl-4,4-difluoro-3,3-dimethylproline methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-N-tert-butoxycarbonyl-4,4-difluoro-3,3-dimethylproline methyl ester

There total 2 articles about (R)-N-tert-butoxycarbonyl-4,4-difluoro-3,3-dimethylproline methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.8%

: 854375-33-0
N-tert-butoxycarbonyl-4,4-difluoro-3,3-dimethylproline methyl ester

: 478698-32-7
1-(tert-butoxycarbonyl)-4,4-difluoro-3,3-dimethylpyrrolidine-2-carboxylic acid

: 854375-31-8
(R)-N-tert-butoxycarbonyl-4,4-difluoro-3,3-dimethylproline methyl ester

Guidance literature:: With sodium hydroxide; alkaline protease from Bacillus licheniformis; In water; acetonitrile; at 30 ℃; for 262h; pH=8; Product distribution / selectivity; Enzymatic reaction;

Reference yield:

: 848444-88-2
C₁₃H₂₁NO₅

: 478698-32-7
1-(tert-butoxycarbonyl)-4,4-difluoro-3,3-dimethylpyrrolidine-2-carboxylic acid

: 854375-31-8
(R)-N-tert-butoxycarbonyl-4,4-difluoro-3,3-dimethylproline methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / 1,2-dichloro-ethane / 70 °C

2: sodium hydroxide; Bacillus licheniformis / acetonitrile / 262 h / 30 °C / pH 8 / Enzymatic reaction

With Bacillus licheniformis; diethylamino-sulfur trifluoride; sodium hydroxide; In 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/op060004+