Technology Process of 3-(2-fluorophenyl)-4-phenylbutanoic acid
There total 6 articles about 3-(2-fluorophenyl)-4-phenylbutanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 2.) piperidine / 1.) H2O, CH3OH, 80 deg C, 10 min; 2.) H2O, CH3OH, reflux, 4 h
2: 72 percent / CH3COOH / methanol / 0.5 h / Heating
3: 81 percent / conc. H2SO4 / acetic acid
4: 65 percent / 10percent NaOH / ethanol; H2O / 10 h / Heating
5: 62 percent / BF3*OEt2 / 0.33 h
6: Raney Ni / ethanol / 6 h / Heating
With
piperidine; sodium hydroxide; sulfuric acid; boron trifluoride diethyl etherate; acetic acid;
nickel;
In
methanol; ethanol; water; acetic acid;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 72 percent / CH3COOH / methanol / 0.5 h / Heating
2: 81 percent / conc. H2SO4 / acetic acid
3: 65 percent / 10percent NaOH / ethanol; H2O / 10 h / Heating
4: 62 percent / BF3*OEt2 / 0.33 h
5: Raney Ni / ethanol / 6 h / Heating
With
sodium hydroxide; sulfuric acid; boron trifluoride diethyl etherate; acetic acid;
nickel;
In
methanol; ethanol; water; acetic acid;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 81 percent / conc. H2SO4 / acetic acid
2: 65 percent / 10percent NaOH / ethanol; H2O / 10 h / Heating
3: 62 percent / BF3*OEt2 / 0.33 h
4: Raney Ni / ethanol / 6 h / Heating
With
sodium hydroxide; sulfuric acid; boron trifluoride diethyl etherate;
nickel;
In
ethanol; water; acetic acid;
