C₁₇H₁₆ClN₃O

Base Information

• Chemical Name: C₁₇H₁₆ClN₃O
• CAS No.: 1426937-43-0
• Molecular Formula: C₁₇H₁₆ClN₃O
• Molecular Weight: 313.787
• Mol file: 1426937-43-0.mol

Synonyms:

Chemical Property of C₁₇H₁₆ClN₃O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₆ClN₃O

There total 4 articles about C₁₇H₁₆ClN₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

1,2,3-triazole (288-36-8) + 5-(3-(bromomethyl)phenoxy)-2-chloro-1,3-dimethylbenzene (1426937-27-0) → C17H16ClN3O (1426937-43-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 3h;

DOI:10.1021/jm400012e

Reference yield:

4-Chloro-3,5-dimethylphenol (88-04-0) → C17H16ClN3O (1426937-43-0)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide; caesium carbonate; dimethylaminoacetic acid / 1,4-dioxane / 16 h / 180 °C

2: lithium bromide; chloro-trimethyl-silane; 1,1,3,3-Tetramethyldisiloxane / acetonitrile / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C

With copper(l) iodide; chloro-trimethyl-silane; dimethylaminoacetic acid; 1,1,3,3-Tetramethyldisiloxane; potassium carbonate; caesium carbonate; lithium bromide; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm400012e

Reference yield:

m-bromobenzoic aldehyde (3132-99-8) → C17H16ClN3O (1426937-43-0)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide; caesium carbonate; dimethylaminoacetic acid / 1,4-dioxane / 16 h / 180 °C

2: lithium bromide; chloro-trimethyl-silane; 1,1,3,3-Tetramethyldisiloxane / acetonitrile / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C

With copper(l) iodide; chloro-trimethyl-silane; dimethylaminoacetic acid; 1,1,3,3-Tetramethyldisiloxane; potassium carbonate; caesium carbonate; lithium bromide; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm400012e

upstream raw materials:

4-Chloro-3,5-dimethylphenol

m-bromobenzoic aldehyde

3-(4-chloro-3,5-dimethylphenoxy)benzaldehyde

1,2,3-triazole