(R)-2-Acetyl-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-3-(3,4,5-trimethoxy-phenyl)-pentanedioic acid 5-tert-butyl ester 1-ethyl ester

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Chemical Name:(R)-2-Acetyl-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-3-(3,4,5-trimethoxy-phenyl)-pentanedioic acid 5-tert-butyl ester 1-ethyl ester
CAS No.:121224-60-0
Molecular Formula:C₃₂H₅₀N₂O₉
Molecular Weight:606.757
Hs Code.:

(R)-2-Acetyl-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-3-(3,4,5-trimethoxy-phenyl)-pentanedioic acid 5-tert-butyl ester 1-ethyl ester

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Chemical Property of (R)-2-Acetyl-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-3-(3,4,5-trimethoxy-phenyl)-pentanedioic acid 5-tert-butyl ester 1-ethyl ester

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Technology Process of (R)-2-Acetyl-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-3-(3,4,5-trimethoxy-phenyl)-pentanedioic acid 5-tert-butyl ester 1-ethyl ester

There total 5 articles about (R)-2-Acetyl-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-3-(3,4,5-trimethoxy-phenyl)-pentanedioic acid 5-tert-butyl ester 1-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141-97-9
ethyl acetoacetate

: 121224-60-0
(R)-2-Acetyl-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-3-(3,4,5-trimethoxy-phenyl)-pentanedioic acid 5-tert-butyl ester 1-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / dioxane / 20 °C / further method: piperidine, HOAc, benzene, reflux

2: 1.) n-BuLi / 1.) -78 deg C, 10 min, 2.) -78 deg C, 1 h

With piperidine; n-butyllithium; In 1,4-dioxane;
DOI:10.1016/S0040-4039(00)82366-7

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 121224-60-0
(R)-2-Acetyl-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-3-(3,4,5-trimethoxy-phenyl)-pentanedioic acid 5-tert-butyl ester 1-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / dioxane / 20 °C / further method: piperidine, HOAc, benzene, reflux

2: 1.) n-BuLi / 1.) -78 deg C, 10 min, 2.) -78 deg C, 1 h

With piperidine; n-butyllithium; In 1,4-dioxane;
DOI:10.1016/S0040-4039(00)82366-7

Reference yield:

: 1694-31-1
tert-butyl acetoacetate

: 121224-60-0
(R)-2-Acetyl-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-3-(3,4,5-trimethoxy-phenyl)-pentanedioic acid 5-tert-butyl ester 1-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

2: 1.) n-BuLi / 1.) -78 deg C, 10 min, 2.) -78 deg C, 1 h

With n-butyllithium;
DOI:10.1016/S0040-4039(00)82366-7