Phosphoric acid (R)-3-(2-{2-[((S)-5-acetylamino-5-carbamoyl-pentylcarbamoyl)-methylsulfanyl]-ethylcarbamoyl}-ethylcarbamoyl)-3-hydroxy-2,2-dimethyl-propyl ester dibenzyl ester

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Chemical Name:Phosphoric acid (R)-3-(2-{2-[((S)-5-acetylamino-5-carbamoyl-pentylcarbamoyl)-methylsulfanyl]-ethylcarbamoyl}-ethylcarbamoyl)-3-hydroxy-2,2-dimethyl-propyl ester dibenzyl ester
CAS No.:639513-14-7
Molecular Formula:C₃₅H₅₂N₅O₁₀PS
Molecular Weight:765.865
Hs Code.:

Phosphoric acid (R)-3-(2-{2-[((S)-5-acetylamino-5-carbamoyl-pentylcarbamoyl)-methylsulfanyl]-ethylcarbamoyl}-ethylcarbamoyl)-3-hydroxy-2,2-dimethyl-propyl ester dibenzyl ester

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Chemical Property of Phosphoric acid (R)-3-(2-{2-[((S)-5-acetylamino-5-carbamoyl-pentylcarbamoyl)-methylsulfanyl]-ethylcarbamoyl}-ethylcarbamoyl)-3-hydroxy-2,2-dimethyl-propyl ester dibenzyl ester

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Technology Process of Phosphoric acid (R)-3-(2-{2-[((S)-5-acetylamino-5-carbamoyl-pentylcarbamoyl)-methylsulfanyl]-ethylcarbamoyl}-ethylcarbamoyl)-3-hydroxy-2,2-dimethyl-propyl ester dibenzyl ester

There total 3 articles about Phosphoric acid (R)-3-(2-{2-[((S)-5-acetylamino-5-carbamoyl-pentylcarbamoyl)-methylsulfanyl]-ethylcarbamoyl}-ethylcarbamoyl)-3-hydroxy-2,2-dimethyl-propyl ester dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 639513-09-0
(S)-2-Acetylamino-6-(2-{2-[3-((R)-2,4-dihydroxy-3,3-dimethyl-butyrylamino)-propionylamino]-ethylsulfanyl}-acetylamino)-hexanoic acid amide

: 639513-14-7
Phosphoric acid (R)-3-(2-{2-[((S)-5-acetylamino-5-carbamoyl-pentylcarbamoyl)-methylsulfanyl]-ethylcarbamoyl}-ethylcarbamoyl)-3-hydroxy-2,2-dimethyl-propyl ester dibenzyl ester

Guidance literature:: Dibenzyl N,N-diisopropylphosphoramidite; (S)-2-Acetylamino-6-(2-{2-[3-((R)-2,4-dihydroxy-3,3-dimethyl-butyrylamino)-propionylamino]-ethylsulfanyl}-acetylamino)-hexanoic acid amide; With 1H-tetrazole; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

With tert.-butylhydroperoxide; In 2,2,4-trimethylpentane; N,N-dimethyl-formamide; at 0 ℃; for 2h;
DOI:10.1016/S0968-0896(03)00265-7

Reference yield:

: 55512-69-1,84256-02-0,496-65-1
pantetheine

: 639513-14-7
Phosphoric acid (R)-3-(2-{2-[((S)-5-acetylamino-5-carbamoyl-pentylcarbamoyl)-methylsulfanyl]-ethylcarbamoyl}-ethylcarbamoyl)-3-hydroxy-2,2-dimethyl-propyl ester dibenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; HCl / H₂O; dioxane / 3 h / 20 °C / pH 2

1.2: 460 mg / triethylamine / H₂O; dioxane / 2.5 h / 20 °C / pH 9.8

2.1: 1H-tetrazole / dimethylformamide / 1 h / 20 °C

2.2: 120 mg / t-butyl hydroperoxide / dimethylformamide; 2,2,4-trimethyl-pentane / 2 h / 0 °C

With 1H-tetrazole; hydrogenchloride; triphenylphosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(03)00265-7

Reference yield:

: 639513-13-6
(S)-2-Acetylamino-6-(2-bromo-acetylamino)-hexanoic acid amide

: 639513-14-7
Phosphoric acid (R)-3-(2-{2-[((S)-5-acetylamino-5-carbamoyl-pentylcarbamoyl)-methylsulfanyl]-ethylcarbamoyl}-ethylcarbamoyl)-3-hydroxy-2,2-dimethyl-propyl ester dibenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; HCl / H₂O; dioxane / 3 h / 20 °C / pH 2

1.2: 460 mg / triethylamine / H₂O; dioxane / 2.5 h / 20 °C / pH 9.8

2.1: 1H-tetrazole / dimethylformamide / 1 h / 20 °C

2.2: 120 mg / t-butyl hydroperoxide / dimethylformamide; 2,2,4-trimethyl-pentane / 2 h / 0 °C

With 1H-tetrazole; hydrogenchloride; triphenylphosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(03)00265-7