(S)-TCFP-RH

Base Information

• Chemical Name: (S)-TCFP-RH
• CAS No.: 705945-68-2
• Molecular Formula: BF₄*C₂₂H₄₄P₂Rh
• Molecular Weight: 560.249
• Mol file: 705945-68-2.mol

Synonyms:

Chemical Property of (S)-TCFP-RH

Chemical Property:

• Melting Point: 171-177 °C
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(S)-(+)-t-Butylmethyl(di-t-butylphosphinomethyl)phosphino(1,5-cyclooctadiene)rhodium(I)tetrafluoroborate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: R-(tert-Butylmethylphosphino-di-tert-butylphosphinomethane)-η4-(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate can be used:In the asymmetric reduction of amines, ketones and unsaturated acids.As a hydrogenation catalyst in the preparation of diastereomers of trifluorovaline.As a catalyst in the olefin asymmetric hydrogenation.

Technology Process of (S)-TCFP-RH

There total 4 articles about (S)-TCFP-RH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

rhodium(I)-bis(1,5-cyclooctadiene) tetrafluoroborate + (R)-tert-butylmethylphosphino-di-tert-butylphosphinomethane (705945-65-9,705945-66-0,864956-85-4) → [((R)-trichickenfootphos)Rh(cod)]BF4 (705945-68-2,705945-70-6,1204139-07-0)

Guidance literature:

In tetrahydrofuran; methanol; at 20 ℃; for 1h; Product distribution / selectivity;

Reference yield:

1,5-cis,cis-cyclooctadiene (1552-12-1,111-78-4) + acetylacetonato(1,5-cyclooctadiene)rhodium(I) + (S)-tert-butylmethylphosphino-di-tert-butylphosphinomethane → [((R)-trichickenfootphos)Rh(cod)]BF4 (705945-68-2,705945-70-6,1204139-07-0)

Guidance literature:

acetylacetonato(1,5-cyclooctadiene)rhodium(I); With tetrafluoroboric acid; In diethyl ether; butanone; for 0.25h;

1,5-cis,cis-cyclooctadiene; In diethyl ether; butanone;

(S)-tert-butylmethylphosphino-di-tert-butylphosphinomethane; In diethyl ether; butanone; Cooling with ice;

Reference yield:

bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate (35138-22-8) + P(CH3)C(CH3)3CH2P(C(CH3)3)2 (705945-65-9,705945-66-0,864956-85-4) → [Rh((S)-TCFP)(cod)]BF4 (705945-70-6,705945-68-2,1204139-07-0)

Guidance literature:

In methanol;

DOI:10.1021/ja048496y

upstream raw materials:

(R)-tert-butylmethylphosphino-di-tert-butylphosphinomethane

bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate

P(CH₃)C(CH₃)3CH₂P(C(CH₃)3)2

1,5-cis,cis-cyclooctadiene

Downstream raw materials:

(Rh(((CH₃)3C)2PCH₂P(CH₃)(C(CH₃)3))(CH₃CONHC(COOCH₃)CHC₆H₅))⁽¹⁺⁾

(Rh(((CH₃)3C)2PCH₂P(CH₃)(C(CH₃)3))(CH₃CONHC(COOCH₃)CHC₆H₅))⁽¹⁺⁾