N-{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ⁵-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Base Information

• Chemical Name: N-{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ⁵-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide
• CAS No.: 145498-69-7
• Molecular Formula: C₃₉H₃₈N₃O₇PS₃
• Molecular Weight: 787.918

Synonyms:

Chemical Property of N-{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ⁵-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

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Technology Process of N-{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ⁵-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

There total 1 articles about N-{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ⁵-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(N,N-diisopropylamino)-1,3,2-dithiaphospholane (145498-60-8) + 4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine (67219-55-0) → N-{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ5-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide (145498-69-7)

Guidance literature:

With 1H-tetrazole; sulfur; Yield given. Multistep reaction; 1.) CH₂Cl₂;

DOI:10.1016/S0040-4039(00)60831-6

Reference yield:

N-{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-2λ5-[1,3,2]dithiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide (145498-69-7) + 3-Hydroxypropionitrile (109-78-4) → C40H38N4O8PS2(1-)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 0.25h; Yield given; Ambient temperature;

DOI:10.1021/jo961801g

upstream raw materials:

2-(N,N-diisopropylamino)-1,3,2-dithiaphospholane

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine

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