(2R,3R)-3,4-dihydro-6-methoxy-2,7,8-trimethyl-2-<(4R,8R)-4,8,12-trimethyltridecyl>-2H-1-benzopyran-3-yl toluene-4-sulfonate

Base Information

• Chemical Name: (2R,3R)-3,4-dihydro-6-methoxy-2,7,8-trimethyl-2-<(4R,8R)-4,8,12-trimethyltridecyl>-2H-1-benzopyran-3-yl toluene-4-sulfonate
• CAS No.: 161661-37-6
• Molecular Formula: C₃₆H₅₆O₅S
• Molecular Weight: 600.904
• Mol file: 161661-37-6.mol

Synonyms:

Chemical Property of (2R,3R)-3,4-dihydro-6-methoxy-2,7,8-trimethyl-2-<(4R,8R)-4,8,12-trimethyltridecyl>-2H-1-benzopyran-3-yl toluene-4-sulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R)-3,4-dihydro-6-methoxy-2,7,8-trimethyl-2-<(4R,8R)-4,8,12-trimethyltridecyl>-2H-1-benzopyran-3-yl toluene-4-sulfonate

There total 10 articles about (2R,3R)-3,4-dihydro-6-methoxy-2,7,8-trimethyl-2-<(4R,8R)-4,8,12-trimethyltridecyl>-2H-1-benzopyran-3-yl toluene-4-sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

p-toluenesulfonyl chloride (98-59-9) + (2R,3R)-3,4-dihydro-6-methoxy-2,7,8-trimethyl-2-<(4R,8R)-4,8,12-trimethyltridecyl>-2H-1-benzopyran-3-ol (162007-73-0) → (2R,3R)-3,4-dihydro-6-methoxy-2,7,8-trimethyl-2-<(4R,8R)-4,8,12-trimethyltridecyl>-2H-1-benzopyran-3-yl toluene-4-sulfonate (161661-37-6)

Guidance literature:

With pyridine; triethylamine; for 12h; Heating;

DOI:10.1002/hlca.19940770705

Reference yield:

(2R,3R)-3,4-dihydro-6-methoxy-2,7,8-trimethyl-2-<(4R,8R)-4,8,12-trimethyltridecyl>-2H-1-benzopyran-3-yl trifluoromethanesulfonate → (2R,3R)-3,4-dihydro-6-methoxy-2,7,8-trimethyl-2-<(4R,8R)-4,8,12-trimethyltridecyl>-2H-1-benzopyran-3-yl toluene-4-sulfonate (161661-37-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 65 percent Chromat_. / 1M LiEt₃BD / tetrahydrofuran / -78 - 21 °C

2: 44 percent / N-bromoacetamide / tetrahydrofuran; H₂O / 6 h / Ambient temperature

3: 1M LiEt₃BH / tetrahydrofuran / 0.33 h / -78 °C

4: 65 percent / Et₃N, pyridine / 12 h / Heating

With pyridine; lithium triethyl borodeuteride; lithium triethylborohydride; triethylamine; N-bromoacetamide; In tetrahydrofuran; water;

DOI:10.1002/hlca.19940770705

Reference yield:

(2R,3S,4R)-3-bromo-3,4-dihydro-6-methoxy-2,7,8-trimethyl-2-<(4R,8R)-4,8,12-trimethyltridecyl>-2H-1-benzopyran-4-ol → (2R,3R)-3,4-dihydro-6-methoxy-2,7,8-trimethyl-2-<(4R,8R)-4,8,12-trimethyltridecyl>-2H-1-benzopyran-3-yl toluene-4-sulfonate (161661-37-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 1M LiEt₃BH / tetrahydrofuran / 0.33 h / -78 °C

2: 2,6-dimethylpyridine / 1 h / -78 - 0 °C

3: 19 percent Chromat_. / 1M LiEt₃BD / tetrahydrofuran / -78 - 21 °C

4: 65 percent / Et₃N, pyridine / 12 h / Heating

With pyridine; 2,6-dimethylpyridine; lithium triethyl borodeuteride; lithium triethylborohydride; triethylamine; In tetrahydrofuran;

DOI:10.1002/hlca.19940770705

upstream raw materials:

p-toluenesulfonyl chloride

(2R,3R)-3,4-dihydro-6-methoxy-2,7,8-trimethyl-2-<(4R,8R)-4,8,12-trimethyltridecyl>-2H-1-benzopyran-3-ol

phytylplastoquinol

(2R,4'R,8'R)-3,4-didehydro-γ-tocopherol