Technology Process of 3-(2-aminoquinolin-3-yl)-N-cyclohexyl-N-methylpropanamide
There total 8 articles about 3-(2-aminoquinolin-3-yl)-N-cyclohexyl-N-methylpropanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
at 80 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1021/jm200544q
- Guidance literature:
-
Multi-step reaction with 7 steps
1: lithium hydroxide monohydrate; water / methanol / 0.67 h / 50 °C / Inert atmosphere
2: thionyl chloride / 1.5 h / 80 °C / Inert atmosphere
3: N-ethyl-N,N-diisopropylamine / dichlorormethane / 0.17 h / 25 °C / Inert atmosphere
4: palladium on activated charcoal; hydrogen / methanol / 3 h
5: 3-chloro-benzenecarboperoxoic acid / chloroform / 1 h / Inert atmosphere; Reflux
6: p-toluenesulfonylanhydride / α,α,α-trifluorotoluene / 0.25 h / Inert atmosphere
7: trifluoroacetic acid / 0.5 h / 80 °C / Inert atmosphere
With
thionyl chloride; lithium hydroxide monohydrate; palladium on activated charcoal; p-toluenesulfonylanhydride; water; hydrogen; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
methanol; dichlorormethane; chloroform; α,α,α-trifluorotoluene;
DOI:10.1021/jm200544q
- Guidance literature:
-
Multi-step reaction with 8 steps
1: tetrahydrofuran / 1.5 h / 60 °C / Inert atmosphere
2: lithium hydroxide monohydrate; water / methanol / 0.67 h / 50 °C / Inert atmosphere
3: thionyl chloride / 1.5 h / 80 °C / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine / dichlorormethane / 0.17 h / 25 °C / Inert atmosphere
5: palladium on activated charcoal; hydrogen / methanol / 3 h
6: 3-chloro-benzenecarboperoxoic acid / chloroform / 1 h / Inert atmosphere; Reflux
7: p-toluenesulfonylanhydride / α,α,α-trifluorotoluene / 0.25 h / Inert atmosphere
8: trifluoroacetic acid / 0.5 h / 80 °C / Inert atmosphere
With
thionyl chloride; lithium hydroxide monohydrate; palladium on activated charcoal; p-toluenesulfonylanhydride; water; hydrogen; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichlorormethane; chloroform; α,α,α-trifluorotoluene;
1: Wittig reaction;
DOI:10.1021/jm200544q
