(6R,8R)-6-Benzenesulfonyl-7-oxo-6,7,9,11,12,13,14,15,16,17-decahydro-cyclopenta[a]phenanthrene-8-carboxylic acid methyl ester

Base Information

• Chemical Name: (6R,8R)-6-Benzenesulfonyl-7-oxo-6,7,9,11,12,13,14,15,16,17-decahydro-cyclopenta[a]phenanthrene-8-carboxylic acid methyl ester
• CAS No.: 113811-96-4
• Molecular Formula: C₂₅H₂₆O₅S
• Molecular Weight: 438.544
• Mol file: 113811-96-4.mol

Synonyms:

Chemical Property of (6R,8R)-6-Benzenesulfonyl-7-oxo-6,7,9,11,12,13,14,15,16,17-decahydro-cyclopenta[a]phenanthrene-8-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6R,8R)-6-Benzenesulfonyl-7-oxo-6,7,9,11,12,13,14,15,16,17-decahydro-cyclopenta[a]phenanthrene-8-carboxylic acid methyl ester

There total 9 articles about (6R,8R)-6-Benzenesulfonyl-7-oxo-6,7,9,11,12,13,14,15,16,17-decahydro-cyclopenta[a]phenanthrene-8-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-pyrrolidinocyclopent-1-ene (7148-07-4) → (6R,8R)-6-Benzenesulfonyl-7-oxo-6,7,9,11,12,13,14,15,16,17-decahydro-cyclopenta[a]phenanthrene-8-carboxylic acid methyl ester (113811-96-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 2.) H₂O / 1.) toluene, reflux, 18 h, 2.) reflux, 30 min

2: TiCl₄, CCl₄, pyridine / tetrahydrofuran / 18 h / 25 °C

3: 89 percent / H₂, 70percent HClO₄ / 5percent Pt/C / methanol / 13 h / 38786.1 Torr

4: 100 percent / NBS, AIBN / CCl₄ / 0.08 h / Heating; Irradiation

5: 28 mg / tert-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran / 0.75 h / Ambient temperature

With pyridine; tetrachloromethane; N-Bromosuccinimide; perchloric acid; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; water; hydrogen; titanium tetrachloride; platinum on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; tert-butyl alcohol;

DOI:10.1021/jo00244a015

Reference yield:

1-(3-hydroxy-1-propyl)-2-<(phenylsulfonyl)methyl>benzene (111170-32-2) → (6R,8R)-6-Benzenesulfonyl-7-oxo-6,7,9,11,12,13,14,15,16,17-decahydro-cyclopenta[a]phenanthrene-8-carboxylic acid methyl ester (113811-96-4)

Guidance literature:

Multi-step reaction with 7 steps

1: triethylamine / CH₂Cl₂ / 3 h / 0 °C

2: NaI / acetone / 2 h / Heating

3: 2.) H₂O / 1.) toluene, reflux, 18 h, 2.) reflux, 30 min

4: TiCl₄, CCl₄, pyridine / tetrahydrofuran / 18 h / 25 °C

5: 89 percent / H₂, 70percent HClO₄ / 5percent Pt/C / methanol / 13 h / 38786.1 Torr

6: 100 percent / NBS, AIBN / CCl₄ / 0.08 h / Heating; Irradiation

7: 28 mg / tert-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran / 0.75 h / Ambient temperature

With pyridine; tetrachloromethane; N-Bromosuccinimide; perchloric acid; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; water; hydrogen; titanium tetrachloride; triethylamine; sodium iodide; platinum on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; acetone; tert-butyl alcohol;

DOI:10.1021/jo00244a015

Reference yield:

1-bromomethyl-2-[(phenylsulfonyl)methyl]benzene (88116-02-3) → (6R,8R)-6-Benzenesulfonyl-7-oxo-6,7,9,11,12,13,14,15,16,17-decahydro-cyclopenta[a]phenanthrene-8-carboxylic acid methyl ester (113811-96-4)

Guidance literature:

Multi-step reaction with 8 steps

1: 1.) NaCl, 2.) LiAlH₄ / 1.) DMSO, H₂O, 160-170 deg C, 4 h, 2.) THF, 0 deg C

2: triethylamine / CH₂Cl₂ / 3 h / 0 °C

3: NaI / acetone / 2 h / Heating

4: 2.) H₂O / 1.) toluene, reflux, 18 h, 2.) reflux, 30 min

5: TiCl₄, CCl₄, pyridine / tetrahydrofuran / 18 h / 25 °C

6: 89 percent / H₂, 70percent HClO₄ / 5percent Pt/C / methanol / 13 h / 38786.1 Torr

7: 100 percent / NBS, AIBN / CCl₄ / 0.08 h / Heating; Irradiation

8: 28 mg / tert-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran / 0.75 h / Ambient temperature

With pyridine; tetrachloromethane; N-Bromosuccinimide; lithium aluminium tetrahydride; perchloric acid; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; water; hydrogen; titanium tetrachloride; triethylamine; sodium iodide; sodium chloride; platinum on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; acetone; tert-butyl alcohol;

DOI:10.1021/jo00244a015

upstream raw materials:

2-{2-[3-(2-Benzenesulfonylmethyl-phenyl)-3-bromo-propyl]-cyclopentyl}-malonic acid dimethyl ester

1-pyrrolidinocyclopent-1-ene

1-(3-hydroxy-1-propyl)-2-<(phenylsulfonyl)methyl>benzene

1-bromomethyl-2-[(phenylsulfonyl)methyl]benzene