Chemical Property of Parecoxib
Edit
Chemical Property:
- Melting Point:165-167°C
- Storage Temp.:Refrigerator
- Solubility.:DMSO (Slightly), Methanol (Slightly)
- Purity/Quality:
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99.0% *data from raw suppliers
Parecoxib *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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Useful:
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Uses
3-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonyl Chloride is an Impurity of Parecoxib Sodium (P193275), an anti-inflammatory, analgesic.
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Clinical Use
Parecoxib is a pro-drug of valdecoxib administered IM or IV for perioperative analgesic and
anti-inflammatory use. As a pro-drug, it undergoes rapid in vivo hydrolysis to valdecoxib.Parecoxib at greater than 20 mg has analgesic activity superior to that of placebo and similar to
that of parenteral 30 or 60 mg of ketorolac in patients with postoperative dental pain. A significant adverse effect is
drug hypersensitivity. Parecoxib is currently marketed worldwide but has not been approved for use in the United
States.
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Drug interactions
Potentially hazardous interactions with other drugs
ACE inhibitors and angiotensin-II antagonists:
antagonism of hypotensive effect; increased risk of
nephrotoxicity and hyperkalaemia.
Analgesics: avoid concomitant use of 2 or more
NSAIDs, including aspirin (increased side effects);
avoid with ketorolac (increased risk of side effects
and haemorrhage).
Antibacterials: possible increased risk of convulsions
with quinolones.
Anticoagulants: effects of coumarins and
phenindione enhanced; possibly increased risk of
bleeding with heparin, dabigatran and edoxaban.
Antidepressants: increased risk of bleeding with
SSRIs and venlafaxine.
Antidiabetics: possibly enhanced effect of
sulphonylureas.
Antiepileptics: possibly enhanced effect of phenytoin.
Antifungals: if used with fluconazole reduce the dose
of parecoxib.
Antivirals: increased risk of haematological toxicity
with zidovudine; concentration possibly increased by
ritonavir.
Ciclosporin: potential for increased risk of
nephrotoxicity.
Cytotoxics: reduced excretion of methotrexate,
(possible increased risk of toxicity); increased risk of
bleeding with erlotinib.
Diuretics: increased risk of nephrotoxicity; possible
antagonism of diuretic effect; increased risk of
hyperkalaemia with potassium-sparing diuretics.
Lithium: reduced excretion of lithium (risk of
toxicity).
Pentoxifylline: possibly increased risk of bleeding.
Tacrolimus: increased risk of nephrotoxicity.
