Piperazine, 1-((2R)-2-amino-1-oxopropyl)-4-(3-(4-(cyclopropylcarbonyl)phenoxy)propyl)-

Base Information

Chemical Name:Piperazine, 1-((2R)-2-amino-1-oxopropyl)-4-(3-(4-(cyclopropylcarbonyl)phenoxy)propyl)-
CAS No.:360551-71-9
Molecular Formula:C₂₀H₂₉N₃O₃
Molecular Weight:359.469
Hs Code.:
UNII:1039LG569Y
DSSTox Substance ID:DTXSID60189623
Nikkaji Number:J1.764.279K
Wikidata:Q27074062
Pharos Ligand ID:JCW7SBKCRAQF
ChEMBL ID:CHEMBL302196

Synonyms:4-((3-(4-(2-aminopropanoyl)-1-piperazinyl)propoxy)phenyl)cyclopropylmethanone;A 304121;A-304121;A304121

Suppliers and Price of Piperazine, 1-((2R)-2-amino-1-oxopropyl)-4-(3-(4-(cyclopropylcarbonyl)phenoxy)propyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of Piperazine, 1-((2R)-2-amino-1-oxopropyl)-4-(3-(4-(cyclopropylcarbonyl)phenoxy)propyl)-

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:359.22089180
Heavy Atom Count:26
Complexity:479

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C(=O)C3CC3)N
Isomeric SMILES:C[C@H](C(=O)N1CCN(CC1)CCCOC2=CC=C(C=C2)C(=O)C3CC3)N

Technology Process of Piperazine, 1-((2R)-2-amino-1-oxopropyl)-4-(3-(4-(cyclopropylcarbonyl)phenoxy)propyl)-

There total 14 articles about Piperazine, 1-((2R)-2-amino-1-oxopropyl)-4-(3-(4-(cyclopropylcarbonyl)phenoxy)propyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: tert-butyl (1S)-2-(4-(3-(4-(cyclopropylcarbonyl)-phenoxy)propyl)-1-piperazinyl)-1-methyl-2-oxoethylcarbamate

: 87-69-4,138508-61-9
L-Tartaric acid

: 360550-43-2,360551-71-9
(4-(3-(4-((2S)-2-aminopropanoyl)-1-piperazinyl)propoxy)phenyl)(cyclopropyl)methanone

Guidance literature:: With trifluoroacetic acid; In methanol; dichloromethane; water;

Reference yield:

: 7150-55-2
γ-chloro-4-hydroxybutyrophenone

: 360551-71-9
A-304121

Guidance literature:: Multi-step reaction with 5 steps

1: NaOH / Heating

2: K₂CO₃ / butan-2-one / 24 h / Heating

3: K₂CO₃; KI / butan-2-one / Heating

4: EDCI; DIEA; DMAP

5: TFA / CH₂Cl₂

With dmap; sodium hydroxide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium iodide; In dichloromethane; butanone;
DOI:10.1016/S0960-894X(02)00310-4

Reference yield:

: 7150-55-2
γ-chloro-4-hydroxybutyrophenone

: 360551-71-9
2-amino-1-{4-[3-(4-cyclopropanecarbonyl-phenoxy)-propyl]-piperazin-1-yl}-propan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: NaOH / Heating

2: K₂CO₃ / butan-2-one / 24 h / Heating

3: K₂CO₃; KI / butan-2-one / Heating

4: EDCI; DIEA; DMAP

5: TFA / CH₂Cl₂

With dmap; sodium hydroxide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium iodide; In dichloromethane; butanone;
DOI:10.1016/S0960-894X(02)00310-4