Technology Process of (s)-2,2-difluoroheptanedioic acid dimethyl ester
There total 5 articles about (s)-2,2-difluoroheptanedioic acid dimethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
diethylamino-sulfur trifluoride;
In
dichloromethane;
at 0 - 20 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: DBN / acetone / 12 h / 0 - 25 °C
2: sulfur dichloride / 12 h / 0 - 65 °C
3: diethylamino-sulfur trifluoride / dichloromethane / 16 h / 0 - 20 °C
With
diethylamino-sulfur trifluoride; DBN; sulfur dichloride;
In
dichloromethane; acetone;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrogenchloride / water / 12 h / 65 °C
2: DBN / acetone / 12 h / 0 - 25 °C
3: sulfur dichloride / 12 h / 0 - 65 °C
4: diethylamino-sulfur trifluoride / dichloromethane / 16 h / 0 - 20 °C
With
hydrogenchloride; diethylamino-sulfur trifluoride; DBN; sulfur dichloride;
In
dichloromethane; water; acetone;
