(2S,4S)-1-[(2S)-2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}-acetamido)-3,3-dimethyl butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

Base Information

Chemical Name:(2S,4S)-1-[(2S)-2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}-acetamido)-3,3-dimethyl butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
CAS No.:2010159-56-3
Molecular Formula:C₃₀H₄₅N₅O₇S
Molecular Weight:619.783
Hs Code.:

(2S,4S)-1-[(2S)-2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}-acetamido)-3,3-dimethyl butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

Synonyms:

Suppliers and Price of (2S,4S)-1-[(2S)-2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}-acetamido)-3,3-dimethyl butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
(S,R,S)-AHPC-PEG3-NH2（E3ligaseLigand-LinkerConjugates5）
003
$ 1700.00

DC Chemicals
(S,R,S)-AHPC-PEG3-NH2（E3ligaseLigand-LinkerConjugates5）
001
$ 500.00

Total 8 raw suppliers

Chemical Property of (2S,4S)-1-[(2S)-2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}-acetamido)-3,3-dimethyl butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

Chemical Property:

Boiling Point:879.2±65.0 °C(Predicted)
Density:1.238±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

(S,R,S)-AHPC-PEG3-NH2（E3ligaseLigand-LinkerConjugates5） ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description (S, R, S)-AHPC-PEG3-amine hydrochloride salt is comprised of VHL Ligand coupled to an amine via a PEG3 linker. The 1 VHL Ligand 1 is a synthetic compound used in PROTAC research based on E3 ligase ligand. NH2 group is reactive with carboxylic acids in the presence of coupling reagent such as EDC , or directly with NHS esters, to form a stable amide bond.

Technology Process of (2S,4S)-1-[(2S)-2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}-acetamido)-3,3-dimethyl butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

There total 27 articles about (2S,4S)-1-[(2S)-2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}-acetamido)-3,3-dimethyl butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (2S,4R)-1-[(2S)-2-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}-acetamido)-3,3-dimethyl-butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

: 2010159-56-3
(2S,4R)-1-[(2S)-2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}-acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; for 3h;
DOI:10.1021/acs.jmedchem.1c01532

Reference yield: 98.0%

: (2S,4S)-1-[(2S)-2-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}-acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

: 2010159-56-3
(2S,4S)-1-[(2S)-2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}-acetamido)-3,3-dimethyl butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 3h; under 4500.45 Torr;
DOI:10.1021/acs.jmedchem.8b01826