clobazam-d3

Base Information

• Chemical Name: clobazam-d3
• CAS No.: 120803-25-0
• Molecular Formula: C₁₆H₁₃ClN₂O₂
• Molecular Weight: 303.721

Synonyms:

Chemical Property of clobazam-d3

Chemical Property:

Purity/Quality:

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Technology Process of clobazam-d3

There total 4 articles about clobazam-d3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

iodomethane-d3 (865-50-9) + N-desmethylclobazam (22316-55-8) → clobazam-d3 (120803-25-0)

Guidance literature:

With sodium ethanolate; In ethanol; for 7h; Heating;

DOI:10.1016/0223-5234(88)90137-7

Reference yield:

5-chloro-2-nitro-N-phenylaniline (25781-92-4) → clobazam-d3 (120803-25-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 4-pyrrolidinopyridine / acetonitrile / 80 °C

2: H₂ / Raney Ni W₂ / methanol / Ambient temperature

3: sodium 2-propanolate / propan-1-ol / Ambient temperature

4: 30 percent / EtONa / ethanol / 7 h / Heating

With hydrogen; sodium ethanolate; sodium isopropylate; 4-pyrrolidin-1-ylpyridine; Raney Ni W₂; In methanol; propan-1-ol; ethanol; acetonitrile;

DOI:10.1016/0223-5234(88)90137-7

Reference yield:

ethyl 2-(N-(5-chloro-2-nitrophenyl)-N-phenylamino)formylacetate (22316-45-6) → clobazam-d3 (120803-25-0)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Raney Ni W₂ / methanol / Ambient temperature

2: sodium 2-propanolate / propan-1-ol / Ambient temperature

3: 30 percent / EtONa / ethanol / 7 h / Heating

With hydrogen; sodium ethanolate; sodium isopropylate; Raney Ni W₂; In methanol; propan-1-ol; ethanol;

DOI:10.1016/0223-5234(88)90137-7

upstream raw materials:

iodomethane-d3

N-desmethylclobazam

N-carbethoxy acetyl N-phenyl 5-chloro o-phenylene diamine

5-chloro-2-nitro-N-phenylaniline

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