3,5-dichloro-4-((R)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-thiazolidine-2-carbonyl)oxy)ethyl)pyridine 1-oxide hydrochloride

Base Information

• Chemical Name: 3,5-dichloro-4-((R)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-thiazolidine-2-carbonyl)oxy)ethyl)pyridine 1-oxide hydrochloride
• CAS No.: 1415995-68-4
• Molecular Formula: C₂₂H₂₂Cl₂F₂N₂O₅S*ClH
• Molecular Weight: 571.857

Synonyms:

Chemical Property of 3,5-dichloro-4-((R)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-thiazolidine-2-carbonyl)oxy)ethyl)pyridine 1-oxide hydrochloride

Chemical Property:

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Technology Process of 3,5-dichloro-4-((R)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-thiazolidine-2-carbonyl)oxy)ethyl)pyridine 1-oxide hydrochloride

There total 2 articles about 3,5-dichloro-4-((R)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-thiazolidine-2-carbonyl)oxy)ethyl)pyridine 1-oxide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-((R)-2-(((S)-3-(tert-butoxycarbonyl)thiazolidine-2-carbonyl)oxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)-3,5-dichloropyridine 1-oxide → 3,5-dichloro-4-((R)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-thiazolidine-2-carbonyl)oxy)ethyl)pyridine 1-oxide hydrochloride (1415995-68-4)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 0.333333h;

DOI:10.1021/acs.jmedchem.7b01044

Reference yield:

→ 3,5-dichloro-4-((R)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-thiazolidine-2-carbonyl)oxy)ethyl)pyridine 1-oxide hydrochloride (1415995-68-4)

Guidance literature:

Reference yield:

3,5-dichloro-4-((R)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-thiazolidine-2-carbonyl)oxy)ethyl)pyridine 1-oxide hydrochloride (1415995-68-4) + 3-[(dimethylamino)carbonyl]benzenesulfonyl chloride (396733-71-4) → 3,5-dichloro-4-((R)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-3-((3-(dimethylcarbamoyl)-phenyl)sulfonyl)thiazolidine-2-carbonyl)oxy)ethyl)pyridine 1-oxide (1415999-45-9) + 3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((3-((3-(dimethylcarbamoyl)-phenyl)sulfonyl)thiazolidine-2-carbonyl)oxy)ethyl)pyridine 1-oxide

Guidance literature:

With pyridine; at 20 ℃; for 4h; Overall yield = 19 %; Overall yield = 35 mg;

DOI:10.1021/acs.jmedchem.7b01044

Downstream raw materials:

3,5-dichloro-4-((R)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-3-((3-(dimethylcarbamoyl)-phenyl)sulfonyl)thiazolidine-2-carbonyl)oxy)ethyl)pyridine 1-oxide

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