(S)-2-((R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-{(2S,4S,5R,6S)-2-(4-methoxy-phenyl)-6-[(E)-2-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-1-methyl-vinyl]-5-methyl-[1,3]dioxan-4-yl}-ethyl)-pent-4-enal

Base Information

Chemical Name:(S)-2-((R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-{(2S,4S,5R,6S)-2-(4-methoxy-phenyl)-6-[(E)-2-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-1-methyl-vinyl]-5-methyl-[1,3]dioxan-4-yl}-ethyl)-pent-4-enal
CAS No.:127516-99-8
Molecular Formula:C₄₄H₇₆O₇Si₂
Molecular Weight:773.254
Hs Code.:

(S)-2-((R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-{(2S,4S,5R,6S)-2-(4-methoxy-phenyl)-6-[(E)-2-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-1-methyl-vinyl]-5-methyl-[1,3]dioxan-4-yl}-ethyl)-pent-4-enal

Synonyms:

Suppliers and Price of (S)-2-((R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-{(2S,4S,5R,6S)-2-(4-methoxy-phenyl)-6-[(E)-2-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-1-methyl-vinyl]-5-methyl-[1,3]dioxan-4-yl}-ethyl)-pent-4-enal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-((R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-{(2S,4S,5R,6S)-2-(4-methoxy-phenyl)-6-[(E)-2-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-1-methyl-vinyl]-5-methyl-[1,3]dioxan-4-yl}-ethyl)-pent-4-enal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-((R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-{(2S,4S,5R,6S)-2-(4-methoxy-phenyl)-6-[(E)-2-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-1-methyl-vinyl]-5-methyl-[1,3]dioxan-4-yl}-ethyl)-pent-4-enal

There total 16 articles about (S)-2-((R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-{(2S,4S,5R,6S)-2-(4-methoxy-phenyl)-6-[(E)-2-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-1-methyl-vinyl]-5-methyl-[1,3]dioxan-4-yl}-ethyl)-pent-4-enal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 127516-99-8
(S)-2-((R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-{(2S,4S,5R,6S)-2-(4-methoxy-phenyl)-6-[(E)-2-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-1-methyl-vinyl]-5-methyl-[1,3]dioxan-4-yl}-ethyl)-pent-4-enal

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-lutidine, / CH₂Cl₂ / 2 h / 0 °C

2: 1) nBuLi / 1) THF, hexane, 30 min, 0 deg C 2) THF, 2h, 0 deg C

With 2,6-dimethylpyridine; n-butyllithium; In dichloromethane;
DOI:10.1021/jo00296a042

Reference yield:

: 116386-68-6
(S)-4-(1-Methylethyl)-3-(1-oxo-4-pentenyl)-2-oxazolidinone

: 127516-99-8
(S)-2-((R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-{(2S,4S,5R,6S)-2-(4-methoxy-phenyl)-6-[(E)-2-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-1-methyl-vinyl]-5-methyl-[1,3]dioxan-4-yl}-ethyl)-pent-4-enal

Guidance literature:: Multi-step reaction with 4 steps

1: 1) nBu₂BOTf, iPr₂NEt 2) 30percent aq. H₂O₂, aq. pH 7 phosphate buffer / 1) CH₂Cl₂, a) 10 min, -78 deg C b) to r.t., 40 min 2) MeOH, 1h

2: 2,6-lutidine, / CH₂Cl₂ / 2 h / 0 °C

3: 1) nBuLi / 1) THF, hexane, 30 min, 0 deg C 2) THF, 2h, 0 deg C

With 2,6-dimethylpyridine; n-butyllithium; pH 7 phosphate buffer; di-n-butylboryl trifluoromethanesulfonate; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jo00296a042

Reference yield:

: 127492-46-0
(1R,2R,4R)-2-Methoxy-4-{(E)-2-[(2S,4S,5R,6S)-2-(4-methoxy-phenyl)-5-methyl-6-vinyl-[1,3]dioxan-4-yl]-propenyl}-cyclohexanol

: 127516-99-8
(S)-2-((R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-{(2S,4S,5R,6S)-2-(4-methoxy-phenyl)-6-[(E)-2-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-1-methyl-vinyl]-5-methyl-[1,3]dioxan-4-yl}-ethyl)-pent-4-enal

Guidance literature:: Multi-step reaction with 7 steps

1: 2,6-lutidine, DMAP / CH₂Cl₂ / 2 h / 0 °C

2: 1) 9-BBN 2) 1N aq. NaOH, 30percent aq. H₂O₂ / 1) THF, 4h, 0 deg C 2) 12h, r.t.

3: 86 percent / Dess-Martin periodinane, pyridine / CH₂Cl₂ / 1.5 h / Ambient temperature

4: 1) nBu₂BOTf, iPr₂NEt 2) 30percent aq. H₂O₂, aq. pH 7 phosphate buffer / 1) CH₂Cl₂, a) 10 min, -78 deg C b) to r.t., 40 min 2) MeOH, 1h

5: 2,6-lutidine, / CH₂Cl₂ / 2 h / 0 °C

6: 1) nBuLi / 1) THF, hexane, 30 min, 0 deg C 2) THF, 2h, 0 deg C

With pyridine; 2,6-dimethylpyridine; dmap; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; pH 7 phosphate buffer; di-n-butylboryl trifluoromethanesulfonate; dihydrogen peroxide; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jo00296a042