(+/-)-virantmycin

Base Information

Chemical Name:(+/-)-virantmycin
CAS No.:104871-16-1
Molecular Formula:C₁₉H₂₆ClNO₃
Molecular Weight:351.873
Hs Code.:

Synonyms:

Suppliers and Price of (+/-)-virantmycin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-virantmycin

Chemical Property:

Purity/Quality:

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Technology Process of (+/-)-virantmycin

There total 33 articles about (+/-)-virantmycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 78983-16-1,104871-13-8,104871-15-0,119239-45-1
(+/-)-virantmycin methyl ester

: 76417-04-4,104871-14-9,104871-16-1,119322-53-1
(+/-)-virantmycin

Guidance literature:: With lithium hydroxide; In water; acetonitrile; at 70 ℃; for 4h;
DOI:10.1016/S0040-4020(01)85583-6

Reference yield:

: 5072-70-8
1-bromo-2,3-dimethyl-2-butene

: 76417-04-4,104871-14-9,104871-16-1,119322-53-1
(+/-)-virantmycin

Guidance literature:: Multi-step reaction with 14 steps

1: 1.)NaH / 1)THF, 2a) 45 deg C, 1,25 h, 2b) r.t., 20 h

2: 65 percent / propane-1,2-diol, Na / 0.5 h / 83 - 85 °C

3: 68 percent / lithium acetylide-ethylendiamine / tetrahydrofuran; benzene / 1.) 35 deg C, 4 h; 2.) 50 deg C, 1.5 h

4: 94 percent / bis(triphenylphosphine)PdCl₂, CuI / diethylamine / 16 h / Ambient temperature

5: 63 percent / aq. methanesulfonic acid / tetrahydrofuran / 20 h / 40 °C

6: NaBH₄ / methanol / Ambient temperature

7: triphenylphosphine / CCl₄ / 5 h / 54 °C

8: 90 percent / 12 h / Ambient temperature

9: 86 percent / m-chloroperbenzoic acid, NaHCO₃ / CH₂Cl₂ / 72 h / Ambient temperature

10: 2.) H₂ / 1.) Raney-Ni, 2) Pd-C / 1.) dioxane, 30 min, 2.) dioxane, 1 atm, 21 h

11: 45 percent / tungsten hexachloride-n-butyl lithium / hexane; tetrahydrofuran / 1.) 3 deg C, 30 min; 2.) r.t., 1 h

12: 80 percent / NaOH / methanol / 20 h / Ambient temperature

13: 45 percent / SOCl₂ / CH₂Cl₂ / 5.5 h / 40 °C

14: 73 percent / LiOH*H₂O / acetonitrile; H₂O / 4 h / 70 °C

With lithium hydroxide; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; thionyl chloride; propylene glycol; methanesulfonic acid; hydrogen; lithium acetylide-ethylenediamine complex; sodium; sodium hydride; tungsten(VI) chloride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; copper(l) iodide; nickel; In tetrahydrofuran; methanol; tetrachloromethane; hexane; dichloromethane; water; diethylamine; acetonitrile; benzene;
DOI:10.1016/S0040-4020(01)85583-6

Reference yield:

: 4-chloro-3a-(3,4-dimethylpent-3-enyl)-7-iodo-3,3a,4,5-tetrahydrooxazolo[3,4-a]quinolin-1-one

: 76417-04-4,104871-14-9,104871-16-1,119322-53-1
(+/-)-virantmycin

Guidance literature:: Multi-step reaction with 4 steps

1: 53 percent / DIBAL-H; n-BuLi / tetrahydrofuran / -78 °C

2: KH / tetrahydrofuran

3: 85 percent / Et₃N; 1,3-bis(diphenylphosphino)propane / Pd(OAc)2 / dimethylformamide / 6 h / 75 °C / 760.05 Torr

4: LiOH; H₂O / acetonitrile

With lithium hydroxide; n-butyllithium; 1,3-bis-(diphenylphosphino)propane; water; potassium hydride; diisobutylaluminium hydride; triethylamine; palladium diacetate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol9908575