N-(4-(2-carbamoylphenylamino)phenyl)-N-methylbenzamide

Base Information

Chemical Name:N-(4-(2-carbamoylphenylamino)phenyl)-N-methylbenzamide
CAS No.:1382353-97-0
Molecular Formula:C₂₁H₁₉N₃O₂
Molecular Weight:345.401
Hs Code.:

Synonyms:

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Chemical Property of N-(4-(2-carbamoylphenylamino)phenyl)-N-methylbenzamide

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Technology Process of N-(4-(2-carbamoylphenylamino)phenyl)-N-methylbenzamide

There total 4 articles about N-(4-(2-carbamoylphenylamino)phenyl)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1382354-41-7
C₂₁H₁₈N₂O₃

: 1382353-97-0
N-(4-(2-carbamoylphenylamino)phenyl)-N-methylbenzamide

Guidance literature:: With ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm3002108

Reference yield:

: 100-15-2
N-methyl(p-nitroaniline)

: 1382353-97-0
N-(4-(2-carbamoylphenylamino)phenyl)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / tetrahydrofuran / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; XPhos / tert-butyl alcohol / Reflux

4: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 20 °C

5: ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; potassium carbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; XPhos; In tetrahydrofuran; methanol; ethanol; water; tert-butyl alcohol; 3: Buchwald-Hartwig reaction;
DOI:10.1021/jm3002108

Reference yield:

: 33672-82-1
N-(4-nitrophenyl)-N-methylbenzamide

: 1382353-97-0
N-(4-(2-carbamoylphenylamino)phenyl)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; XPhos / tert-butyl alcohol / Reflux

3: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 20 °C

4: ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; potassium carbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; XPhos; In tetrahydrofuran; methanol; ethanol; water; tert-butyl alcohol; 2: Buchwald-Hartwig reaction;
DOI:10.1021/jm3002108